ChemicalBook > CAS DataBase List > perimetazine

perimetazine

Product Name
perimetazine
CAS No.
13093-88-4
Chemical Name
perimetazine
Synonyms
RP-9159;RP 9159;Leptryl;AN-1317;AN 1317;perimetazine;1-[3-(2-methoxyphenothiazin-10-yl)-2-methylpropyl]piperidin-4-ol;1-(3-(2-Methoxy-10H-phenothiazin-10-yl)-2-methylpropyl)piperidin-4-ol;4-Piperidinol, 1-[3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]-
CBNumber
CB0936936
Molecular Formula
C22H28N2O2S
Formula Weight
384.541
MOL File
13093-88-4.mol
More
Less

perimetazine Property

Melting point:
137-138°
Boiling point:
569.1±50.0 °C(Predicted)
Density 
1.0944 (rough estimate)
refractive index 
1.6000 (estimate)
pka
14.87±0.20(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
P287000
Product name
Perimethazine
Packaging
250mg
Price
$165
Updated
2021/12/16
TRC
Product number
P287000
Product name
Perimethazine
Packaging
2.5g
Price
$1320
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
61034
Product name
Perimethazine
Packaging
2.5g
Price
$2200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012224
Product name
PERIMETAZINE
Purity
95.00%
Packaging
5MG
Price
$498.87
Updated
2021/12/16
More
Less

perimetazine Chemical Properties,Usage,Production

Originator

Leptryl ,Roger Bellon, France,1970

Uses

Perimethazine, is a novel Antipsychotic drug. It has shown to cause sedation, hypothermia, muscle relaxation, and other signs of central depression in rabbits.

Definition

ChEBI: Perimetazine is a member of phenothiazines.

Manufacturing Process

A solution of 3-methoxy-10-(3-chloro-2-methylpropyl)phenthiazine (9.65 grams) and 4-hydroxypiperidine (6.1 grams) in xylene (10 cc) is heated under reflux for 5 hours. After cooling the mixture is diluted with ether (60 cc) and the basic compounds are extracted by agitation with water (30 cc) and 4 N hydrochloric acid (20 cc). The aqueous acid phase is made alkaline with 4 N sodium hydroxide solution (23 cc) and the liberated base is extracted with ether. The ethereal solution is washed with water (60 cc) and dried over sodium sulfate. Finally the solvent is distilled off on a water-bath.
The solid residue obtained is recrystallized from a mixture (15:85) of benzene and cyclohexane and there is obtained 3-rnethoxy-10-[2-methyl-3-(4hydroxy-1-piperidyl)-propyl]-phenthiazine (5.7 grams) as a white crystalline powder, MP 137°-138°C.

Therapeutic Function

Tranquilizer

perimetazine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

perimetazine Suppliers

13093-88-4, perimetazineRelated Search:


  • 1-(3-(2-Methoxy-10H-phenothiazin-10-yl)-2-methylpropyl)piperidin-4-ol
  • perimetazine
  • AN 1317
  • AN-1317
  • Leptryl
  • RP 9159
  • RP-9159
  • 1-[3-(2-methoxyphenothiazin-10-yl)-2-methylpropyl]piperidin-4-ol
  • 4-Piperidinol, 1-[3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]-
  • 13093-88-4