perimetazine
- Product Name
- perimetazine
- CAS No.
- 13093-88-4
- Chemical Name
- perimetazine
- Synonyms
- RP-9159;RP 9159;Leptryl;AN-1317;AN 1317;perimetazine;1-[3-(2-methoxyphenothiazin-10-yl)-2-methylpropyl]piperidin-4-ol;1-(3-(2-Methoxy-10H-phenothiazin-10-yl)-2-methylpropyl)piperidin-4-ol;4-Piperidinol, 1-[3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]-
- CBNumber
- CB0936936
- Molecular Formula
- C22H28N2O2S
- Formula Weight
- 384.541
- MOL File
- 13093-88-4.mol
perimetazine Property
- Melting point:
- 137-138°
- Boiling point:
- 569.1±50.0 °C(Predicted)
- Density
- 1.0944 (rough estimate)
- refractive index
- 1.6000 (estimate)
- pka
- 14.87±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- P287000
- Product name
- Perimethazine
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- P287000
- Product name
- Perimethazine
- Packaging
- 2.5g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- 61034
- Product name
- Perimethazine
- Packaging
- 2.5g
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- API0012224
- Product name
- PERIMETAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.87
- Updated
- 2021/12/16
perimetazine Chemical Properties,Usage,Production
Originator
Leptryl ,Roger Bellon, France,1970
Uses
Perimethazine, is a novel Antipsychotic drug. It has shown to cause sedation, hypothermia, muscle relaxation, and other signs of central depression in rabbits.
Definition
ChEBI: Perimetazine is a member of phenothiazines.
Manufacturing Process
A solution of 3-methoxy-10-(3-chloro-2-methylpropyl)phenthiazine (9.65 grams) and 4-hydroxypiperidine (6.1 grams) in xylene (10 cc) is heated under reflux for 5 hours. After cooling the mixture is diluted with ether (60 cc) and the basic compounds are extracted by agitation with water (30 cc) and 4 N hydrochloric acid (20 cc). The aqueous acid phase is made alkaline with 4 N sodium hydroxide solution (23 cc) and the liberated base is extracted with ether. The ethereal solution is washed with water (60 cc) and dried over sodium sulfate. Finally the solvent is distilled off on a water-bath.
The solid residue obtained is recrystallized from a mixture (15:85) of benzene and cyclohexane and there is obtained 3-rnethoxy-10-[2-methyl-3-(4hydroxy-1-piperidyl)-propyl]-phenthiazine (5.7 grams) as a white crystalline powder, MP 137°-138°C.
Therapeutic Function
Tranquilizer