Adverse Reactions
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Medetomidine

Adverse Reactions
Product Name
Medetomidine
CAS No.
86347-14-0
Chemical Name
Medetomidine
Synonyms
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;DoMtor;CS-849;Medetomidin;Medetomidine;Medetomidina;Medetomidinum;dl-Medetomidine;Medetomidine-D5;Medetomidine, BR
CBNumber
CB0951588
Molecular Formula
C13H16N2
Formula Weight
200.28
MOL File
86347-14-0.mol
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Medetomidine Property

Boiling point:
381.9±11.0 °C(Predicted)
Density 
1.053
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO
pka
14.29±0.10(Predicted)
form 
Powder
color 
White to off-white
InChI
InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)
InChIKey
CUHVIMMYOGQXCV-UHFFFAOYSA-N
SMILES
C1NC(C(C2=CC=CC(C)=C2C)C)=CN=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H330Fatal if inhaled

H336May cause drowsiness or dizziness

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0734
Product name
Medetomidine
Purity
99.97%
Packaging
10mg
Price
$80
Updated
2021/12/16
ApexBio Technology
Product number
A3592
Product name
Medetomidine
Packaging
5mg
Price
$88
Updated
2021/12/16
AK Scientific
Product number
3506AC
Product name
Medetomidine
Packaging
25mg
Price
$145
Updated
2021/12/16
ChemScene
Product number
CS-0734
Product name
Medetomidine
Purity
99.97%
Packaging
50mg
Price
$240
Updated
2021/12/16
AK Scientific
Product number
J55251
Product name
4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole
Packaging
250mg
Price
$245
Updated
2021/12/16
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Medetomidine Chemical Properties,Usage,Production

Adverse Reactions

As with all α2-agonists, the potential for isolated cases of hypersensitivity, including paradoxical response (excitation), exists. Incidents of prolonged sedation, bradycardia, cyanosis, vomiting, apnea, death from circulatory failure with severe congestion of lungs, liver, kidney and recurrence of sedation after initial recovery have been reported.

Description

Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist. The drug has been developed by Orion Pharma. In the United States, it is currently approved for its veterinary use in dogs and distributed by Pfizer Animal Health. In Canada, medetomidine is distributed by Novartis Animal Health. The marketed product is a racemic mixture of two stereoisomers from which dexmedetomidine is the main active isomer.

Uses

Analgesic (veterinary); sedative (veterinary).

Uses

Medetomidine is used in method for synthesizing Medetomidine using 2,3-Dimethylphenylmagnesium Bromide.

Indications

Medetomidine Hydrochloride is indicated for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations, clinical procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures where intubation is not required. The IV route of administration is more efficacious for dental care.

Definition

ChEBI: Medetomidine is a member of imidazoles.

Clinical Use

Medetomidine is a potent non-narcotic α2-adrenoreceptor agonist which produces sedation and analgesia. These effects are dose dependent in depth and duration. Profound sedation and recumbency, with reduced sensitivity to environmental stimuli (sounds, etc.), are seen with medetomidine.

Side effects

Bradycardia with occasional atrioventricular blocks will occur together with decreased respiratory rates. Body temperature is slightly or moderately decreased. Urination typically occurs during recovery at about 90 to 120 minutes posttreatment. In approximately 10% of treated dogs, occasional episodes of vomiting occur between 5 to 15 minutes posttreatment. An increase in blood glucose concentration is seen due to α2-adrenoreceptor-mediated inhibition of insulin secretion.

Veterinary Drugs and Treatments

Medetomidine is labeled for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations and procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures not requiring intubation. The manufacturer recommends the IV route of administration for dental procedures. Medetomidine has also been used in cats, primarily in Europe. But there is apparently much less data available to evaluate its use; caution is advised.

Precautions

In extremely nervous or excited dogs, levels of endogenous catecholamines are high due to the animal’s state of agitation. The pharmacological response elicited by α2-agonists (e.g., medetomidine) in such animals is often reduced, with depth and duration of sedative/analgesic effects ranging from slightly diminished to nonexistent. Highly agitated dogs should therefore be put at ease and allowed to rest quietly prior to receiving Medetomidine Hydrochloride. Allowing dogs to rest quietly for 10 to 15 minutes after injection may improve the response to Medetomidine Hydrochloride. In dogs not responding satisfactorily to treatment with Medetomidine Hydrochloride, repeat dosing is not recommended.

Medetomidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Medetomidine Suppliers

CHENGHUI PHARMACEUTICAL GROUP LTD
Tel
0531-58897070 15254140813
Fax
0531-58897046
Email
market@jnchsd.com
Country
China
ProdList
213
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 17825480238
Fax
QQ 3008233717
Email
3008233717@qq.com
Country
China
ProdList
9919
Advantage
12
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Jinan Chenghui Shuangda biological Co., LTD
Tel
0531-58897003 15550412551
Fax
0531-58897003
Email
market@jnchsd.com
Country
China
ProdList
211
Advantage
62
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Chengdu Yuyang High-Tech Developing Co., Ltd
Tel
+86-28-61777709
Fax
+86-28-61777709
Email
yygk@yygk.com
Country
China
ProdList
69
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
ShangHai Onsyn-Chemical Technology Co., Ltd.
Tel
021-58359326 13124831025
Fax
+86-21-58359326
Email
angsihuaxue@126.com
Country
China
ProdList
246
Advantage
55
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View Lastest Price from Medetomidine manufacturers

Dorne Chemical Technology co. LTD
Product
Medetomidine 86347-14-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
Jinan Million Pharmaceutical Co., Ltd
Product
Medetomidine 86347-14-0
Price
US $6.00/kg
Min. Order
1kg
Purity
99.56
Supply Ability
60 tons
Release date
2024-09-28
Wuhan Haorong Biotechnology Co.,Ltd
Product
Medetomidine 86347-14-0
Price
US $1.00/KG
Min. Order
0.01KG
Purity
99%
Supply Ability
2000 tons
Release date
2024-09-26

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