Dexmedetomidine

Product Name: Dexmedetomidine
CAS No.: 113775-47-6
Chemical Name: Dexmedetomidine
Synonyms: MPV 1440;d-Medetomidine;DEXMEDETOMIDINE;(S)-Medetomidine;(+)-Medetomidine;Dexmedetomidine D6;Medetomidine (S)-Isomer;Medetomidine Impurity 56;DexmedetomidineHclC13H16N2.Hcl;DexmedetomidineHclC13H16N2.Hcl USP/EP/BP
CBNumber: CB41017166
Molecular Formula: C13H16N2
Formula Weight: 200.28
MOL File: 113775-47-6.mol

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Dexmedetomidine Property

Melting point:: 146-149°C
Boiling point:: 381.9±11.0 °C(Predicted)
Density: 1.053±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO > 10 mM
form: Powder
pka: 13.89±0.10(Predicted)
InChI: InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1
InChIKey: CUHVIMMYOGQXCV-NSHDSACASA-N
SMILES: C1NC([C@H](C2=CC=CC(C)=C2C)C)=CN=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H360May damage fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D299000
Product name: Dexmedetomidine
Packaging: 100mg
Price: $180
Updated: 2021/12/16

ApexBio Technology

Product number: B1334
Product name: Dexmedetomidine
Packaging: 10mM(in 1mL DMSO)
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0012295
Product name: Dexmedetomidine
Purity: ≥99.0%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

Activate Scientific

Product number: AS93603
Product name: (S)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
Purity: 97+% ee
Packaging: 1g
Price: $351
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000529
Product name: DEXMEDETOMIDINE
Purity: 95.00%
Packaging: 10MG
Price: $721.88
Updated: 2021/12/16

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Dexmedetomidine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Dexmedetomidine is a sedative drug that has many benefits when given to children under anesthesia, such as improved pain relief and reduced agitation following their surgery. The FDA-approved indications for dexmedetomidine are sedation of intubated and mechanically ventilated patients in the intensive care unit (ICU) and peri-procedural (or peri-operative) sedation of non-intubated patients.

Definition

ChEBI: Dexmedetomidine is a medetomidine. It has a role as an alpha-adrenergic agonist, a non-narcotic analgesic, an analgesic and a sedative. It is an enantiomer of a levomedetomidine.

brand name

Precedex (Hospira).

Side effects

This drug is most commonly given to cause sedation, so extreme sedation/lethargy for a short period of time is an expected side effect. Pale gums and lowered heart and respiratory rates can occur. Rarely, vomiting, diarrhea, and collapse may occur. When injected into the muscle, this medication can cause temporary pain at the injection site.

Mode of action

The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord.

References

https://www.statpearls.com/articlelibrary/viewarticle/20424/
https://pubchem.ncbi.nlm.nih.gov/compound/dexmedetomidine
https://www.drugs.com/mtm/dexmedetomidine.html
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting DOI: 10.1007/s40265-015-0419-5

Dexmedetomidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Dexmedetomidine Suppliers

Canada 2 China 136 Europe 2 Germany 1 India 7 South Korea 1 United Kingdom 1 United States 10 Global 160

Suzhou Tianhong Medicine Chemical Technology Co.,Ltd.

Tel: 18949937116
Email: dongye.huaxue@126.com
Country: China
ProdList: 45
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 17987
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Chengdu Yuyang High-Tech Developing Co., Ltd

Tel: +86-28-61777709
Fax: +86-28-61777709
Email: yygk@yygk.com
Country: China
ProdList: 69
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 1989
Advantage: 60

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

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View Lastest Price from Dexmedetomidine manufacturers

CONTIDE BIOTECH CO.,LTD

Product: Dexmedetomidine 113775-47-6
Price: US $0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 20
Release date: 2024-04-11

Henan Tengmao Chemical Technology Co. LTD

Product: Dexmedetomidine 113775-47-6
Price: US $110.00-90.00/kilogram
Min. Order: 1kilogram
Purity: 99%
Supply Ability: 10 tons/per week
Release date: 2024-01-09

Xiamen Wonderful Bio Technology Co., Ltd.

Product: Dexmedetomidine 113775-47-6
Price: US $88.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000T
Release date: 2023-07-24

113775-47-6, DexmedetomidineRelated Search:

METARAMINOL Tropisetron Rocuronium bromide ENALAPRILAT DIHYDRATE Yohimbine hydrochloride OLIGOMYCIN A Belinostat (PXD101) Entinostat Pregnenolone 4-(2,3-DIMETHYL-BENZYL)-1H-IMIDAZOLE Dexmedetomidine hydrochloride Dexmedetomidine Medetomidine

(+)-4-[(S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole

4-[(S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole

DexmedetomidineHclC13H16N2.Hcl

Dexmedetomidine Hcl C13H16N2.Hcl 145108-58-3(Hcl)

(S)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole

(S)-Medetomidine

5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole

d-Medetomidine

MPV 1440

1H-IMidazole,5-[(1S)-1-(2,3-diMethylphenyl)ethyl]-

(S)-5-(1-(2,3-diMethylphenyl)ethyl)-1H-iMidazole

4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

Medetomidine (S)-Isomer

DexmedetomidineHclC13H16N2.Hcl USP/EP/BP

Medetomidine Impurity 56

Dexmedetomidine D6

CAS 113775-47-6 DexmedetomidineHclC13H16N2.Hcl

(+)-Medetomidine

DEXMEDETOMIDINE

analgesia,Inhibitor,(S)-Medetomidine,adrenoceptor,inhibit,(+)-Medetomidine,Beta Receptor,sedation,Adrenergic Receptor,Dexmedetomidine,anxiolysis

Medetomidine Impurity 56(Dexmedetomidine)

113775-47-6

Aromatics Compounds

Aromatics

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitors