Dexmedetomidine
- Product Name
- Dexmedetomidine
- CAS No.
- 113775-47-6
- Chemical Name
- Dexmedetomidine
- Synonyms
- MPV 1440;d-Medetomidine;DEXMEDETOMIDINE;(S)-Medetomidine;(+)-Medetomidine;Dexmedetomidine D6;Medetomidine (S)-Isomer;Medetomidine Impurity 56;DexmedetomidineHclC13H16N2.Hcl;DexmedetomidineHclC13H16N2.Hcl USP/EP/BP
- CBNumber
- CB41017166
- Molecular Formula
- C13H16N2
- Formula Weight
- 200.28
- MOL File
- 113775-47-6.mol
Dexmedetomidine Property
- Melting point:
- 146-149°C
- Boiling point:
- 381.9±11.0 °C(Predicted)
- Density
- 1.053±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 13.89±0.10(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1
- InChIKey
- CUHVIMMYOGQXCV-NSHDSACASA-N
- SMILES
- C1NC([C@H](C2=CC=CC(C)=C2C)C)=CN=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H360May damage fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D299000
- Product name
- Dexmedetomidine
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- B1334
- Product name
- Dexmedetomidine
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-0012295
- Product name
- Dexmedetomidine
- Purity
- ≥99.0%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- AS93603
- Product name
- (S)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
- Purity
- 97+% ee
- Packaging
- 1g
- Price
- $351
- Updated
- 2021/12/16
- Product number
- API0000529
- Product name
- DEXMEDETOMIDINE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $721.88
- Updated
- 2021/12/16
Dexmedetomidine Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Dexmedetomidine is a sedative drug that has many benefits when given to children under anesthesia, such as improved pain relief and reduced agitation following their surgery. The FDA-approved indications for dexmedetomidine are sedation of intubated and mechanically ventilated patients in the intensive care unit (ICU) and peri-procedural (or peri-operative) sedation of non-intubated patients.
Definition
ChEBI: Dexmedetomidine is a medetomidine. It has a role as an alpha-adrenergic agonist, a non-narcotic analgesic, an analgesic and a sedative. It is an enantiomer of a levomedetomidine.
brand name
Precedex (Hospira).
Side effects
This drug is most commonly given to cause sedation, so extreme sedation/lethargy for a short period of time is an expected side effect. Pale gums and lowered heart and respiratory rates can occur. Rarely, vomiting, diarrhea, and collapse may occur. When injected into the muscle, this medication can cause temporary pain at the injection site.
Mode of action
The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord.
References
https://www.statpearls.com/articlelibrary/viewarticle/20424/
https://pubchem.ncbi.nlm.nih.gov/compound/dexmedetomidine
https://www.drugs.com/mtm/dexmedetomidine.html
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting DOI: 10.1007/s40265-015-0419-5
Dexmedetomidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dexmedetomidine manufacturers
- Product
- Dexmedetomidine 113775-47-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2024-09-18
- Product
- Dexmedetomidine 113775-47-6
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-09-14
- Product
- Dexmedetomidine 113775-47-6
- Price
- US $88.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000T
- Release date
- 2023-07-24