KIRENOL
- Product Name
- KIRENOL
- CAS No.
- 52659-56-0
- Chemical Name
- KIRENOL
- Synonyms
- Kirel;Kirenol;KIRENOL(P);(1R)-1-[(2S,4aR,4bS,6S,8R,8aS)-6-hydroxy-8-(hydroxymethyl)-2,4b,8-trimethyl-4,4a,5,6,7,8a,9,10-octahydro-3H-phenanthren-2-yl]ethane-1,2-diol;(1R,3S,4aS,4bS,7S,10aS)-1,2,3,4,4a,4b,5,6,7,9,10,10a-Dodecahydro-3-hydroxy-7-[(R)-1,2-dihydroxyethyl]-1,4a,7-trimethylphenanthrene-1-methanol;1,7-Phenanthrenedimethanol, 1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-3-hydroxy-α7-(hydroxymethyl)-1,4a,7-trimethyl-, (α7R,1R,3S,4aS,4bR,7S,10aS)-;1,7-PhenanthrenediMethanol,1,2,3,4,4a,4b,5,6,7,- 9,10,10a-dodecahydro-3-hydroxy-R7- (hydroxyMethyl)-1,4a,7-triMethyl-,(R7R,1R,- 3S,4aS,4bR,7S,10aS)-;KirenolQ: What is Kirenol Q: What is the CAS Number of Kirenol Q: What is the storage condition of Kirenol Q: What are the applications of Kirenol
- CBNumber
- CB0955980
- Molecular Formula
- C20H34O4
- Formula Weight
- 338.49
- MOL File
- 52659-56-0.mol
KIRENOL Property
- Melting point:
- 197.0 to 201.0 °C
- Boiling point:
- 516.9±35.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.06±0.20(Predicted)
- color
- White to Light Yellow
- CAS DataBase Reference
- 52659-56-0
Safety
- Safety Statements
- 24/25
- RTECS
- SF7352310
- HS Code
- 29399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- K0059
- Product name
- Kirenol
- Purity
- >98.0%(GC)
- Packaging
- 25mg
- Price
- $194
- Updated
- 2024/03/01
- Product number
- K0059
- Product name
- Kirenol
- Purity
- >98.0%(GC)
- Packaging
- 100mg
- Price
- $580
- Updated
- 2024/03/01
- Product number
- 26212
- Product name
- Kirenol
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 26212
- Product name
- Kirenol
- Packaging
- 50mg
- Price
- $293
- Updated
- 2021/12/16
- Product number
- 26212
- Product name
- Kirenol
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
KIRENOL Chemical Properties,Usage,Production
Description
Kirenol is a diterpenoid that has been found in S. orientalis and has diverse biological activities, including anti-arthritic and anti-inflammatory properties. It inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays with MICs ranging from 39 to 156 and 312.5 to 625 μg/ml, respectively. Kirenol also reduces K652 chronic myeloid leukemia cell viability with a 48 hour IC50 value of 18.19 μg/ml and induces apoptosis. In vivo, kirenol (2 mg/kg, p.o.) reduces motor deficit, delays disease onset by approximately five days, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th17 cells in a mouse model of experimental autoimmune encephalomyelitis (EAE). Intragastric administration of kirenol (1-4 mg/kg) reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression without affecting glucocorticoid receptor α (GRα) expression in the synovium in a rat model of collagen-induced arthritis. Topical administration of kirenol (0.3-0.5% w/w) reduces edema induced by carrageenan, complete Freund''s adjuvant (CFA), and formalin in rats up to 44, 67, and 65%, respectively.
Uses
Kirenol is a pharmaceutical agent that induces apoptosis in human chronic myeloid leukemia cells.
Definition
ChEBI: Kirenol is a diterpenoid.
KIRENOL Preparation Products And Raw materials
Raw materials
Preparation Products
KIRENOL Suppliers
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View Lastest Price from KIRENOL manufacturers
- Product
- Kirenol 52659-56-0
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-09-16
- Product
- Kirenol 52659-56-0
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- Analytical Standard
- Supply Ability
- 10 g
- Release date
- 2019-09-16
- Product
- KIRENOL 52659-56-0
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24