KIRENOL

Product Name: KIRENOL
CAS No.: 52659-56-0
Chemical Name: KIRENOL
Synonyms: Kirel;Kirenol;KIRENOL(P);(1R)-1-[(2S,4aR,4bS,6S,8R,8aS)-6-hydroxy-8-(hydroxymethyl)-2,4b,8-trimethyl-4,4a,5,6,7,8a,9,10-octahydro-3H-phenanthren-2-yl]ethane-1,2-diol;(1R,3S,4aS,4bS,7S,10aS)-1,2,3,4,4a,4b,5,6,7,9,10,10a-Dodecahydro-3-hydroxy-7-[(R)-1,2-dihydroxyethyl]-1,4a,7-trimethylphenanthrene-1-methanol;1,7-Phenanthrenedimethanol, 1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-3-hydroxy-α7-(hydroxymethyl)-1,4a,7-trimethyl-, (α7R,1R,3S,4aS,4bR,7S,10aS)-;(R)-1-((2S,4aR,4bS,6S,8R,8aS)-6-Hydroxy-8-(hydroxymethyl)-2,4b,8-trimethyl-2,3,4,4a,4b,5,6,7,8,8a,9,10-dodecahydrophenanthren-2-yl)ethane-1,2-diol;1,7-PhenanthrenediMethanol,1,2,3,4,4a,4b,5,6,7,- 9,10,10a-dodecahydro-3-hydroxy-R7- (hydroxyMethyl)-1,4a,7-triMethyl-,(R7R,1R,- 3S,4aS,4bR,7S,10aS)-;KirenolQ: What is Kirenol Q: What is the CAS Number of Kirenol Q: What is the storage condition of Kirenol Q: What are the applications of Kirenol
CBNumber: CB0955980
Molecular Formula: C20H34O4
Formula Weight: 338.49
MOL File: 52659-56-0.mol

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KIRENOL Property

Melting point:: 197.0 to 201.0 °C
Boiling point:: 516.9±35.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 14.06±0.20(Predicted)
color: White to Light Yellow
CAS DataBase Reference: 52659-56-0

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Safety

Safety Statements: 24/25
RTECS: SF7352310
HS Code: 29399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: K0059
Product name: Kirenol
Purity: >98.0%(GC)
Packaging: 25mg
Price: $194
Updated: 2024/03/01

TCI Chemical

Product number: K0059
Product name: Kirenol
Purity: >98.0%(GC)
Packaging: 100mg
Price: $580
Updated: 2024/03/01

Cayman Chemical

Product number: 26212
Product name: Kirenol
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 26212
Product name: Kirenol
Packaging: 50mg
Price: $293
Updated: 2021/12/16

Cayman Chemical

Product number: 26212
Product name: Kirenol
Packaging: 5mg
Price: $62
Updated: 2024/03/01

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KIRENOL Chemical Properties,Usage,Production

Description

Kirenol is a diterpenoid that has been found in S. orientalis and has diverse biological activities, including anti-arthritic and anti-inflammatory properties. It inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays with MICs ranging from 39 to 156 and 312.5 to 625 μg/ml, respectively. Kirenol also reduces K652 chronic myeloid leukemia cell viability with a 48 hour IC₅₀ value of 18.19 μg/ml and induces apoptosis. In vivo, kirenol (2 mg/kg, p.o.) reduces motor deficit, delays disease onset by approximately five days, and downregulates inflammatory CD4⁺IFN-γ⁺ Th1 cells and CD4⁺IL-17A⁺ Th17 cells in a mouse model of experimental autoimmune encephalomyelitis (EAE). Intragastric administration of kirenol (1-4 mg/kg) reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression without affecting glucocorticoid receptor α (GRα) expression in the synovium in a rat model of collagen-induced arthritis. Topical administration of kirenol (0.3-0.5% w/w) reduces edema induced by carrageenan, complete Freund''s adjuvant (CFA), and formalin in rats up to 44, 67, and 65%, respectively.

Uses

Kirenol is a pharmaceutical agent that induces apoptosis in human chronic myeloid leukemia cells.

Definition

ChEBI: Kirenol is a diterpenoid.

KIRENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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KIRENOL Suppliers

Americas 1 Canada 1 China 161 Europe 1 Germany 1 India 2 Japan 1 United Kingdom 2 United States 12 Global 182

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

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View Lastest Price from KIRENOL manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Kirenol 52659-56-0
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-16

Shanghai Standard Technology Co., Ltd.

Product: Kirenol 52659-56-0
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-09-16

Career Henan Chemical Co

Product: KIRENOL 52659-56-0
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

52659-56-0, KIRENOLRelated Search:

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(1R,3S,4aS,4bS,7S,10aS)-1,2,3,4,4a,4b,5,6,7,9,10,10a-Dodecahydro-3-hydroxy-7-[(R)-1,2-dihydroxyethyl]-1,4a,7-trimethylphenanthrene-1-methanol

Kirenol

KIRENOL(P)

Kirel

1,7-PhenanthrenediMethanol,1,2,3,4,4a,4b,5,6,7,- 9,10,10a-dodecahydro-3-hydroxy-R7- (hydroxyMethyl)-1,4a,7-triMethyl-,(R7R,1R,- 3S,4aS,4bR,7S,10aS)-

1,7-Phenanthrenedimethanol, 1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-3-hydroxy-α7-(hydroxymethyl)-1,4a,7-trimethyl-, (α7R,1R,3S,4aS,4bR,7S,10aS)-

(1R)-1-[(2S,4aR,4bS,6S,8R,8aS)-6-hydroxy-8-(hydroxymethyl)-2,4b,8-trimethyl-4,4a,5,6,7,8a,9,10-octahydro-3H-phenanthren-2-yl]ethane-1,2-diol

KirenolQ: What is Kirenol Q: What is the CAS Number of Kirenol Q: What is the storage condition of Kirenol Q: What are the applications of Kirenol

(R)-1-((2S,4aR,4bS,6S,8R,8aS)-6-Hydroxy-8-(hydroxymethyl)-2,4b,8-trimethyl-2,3,4,4a,4b,5,6,7,8,8a,9,10-dodecahydrophenanthren-2-yl)ethane-1,2-diol

52659-56-0

C2OH34O4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

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