ChemicalBook > CAS DataBase List > (S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester

(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester

Product Name
(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester
CAS No.
313706-15-9
Chemical Name
(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester
Synonyms
(S)-Methyl 1-Boc-pyrrolid...;(R)-1-tert-butyl 3-methyl pyrrolidine-;(S)-1-Boc-pyrrolidine-1,3-dicarboxylate;Methyl (S)-1-Boc-pyrrolidine-3-carboxylate;(S)-Methyl 1-Boc-pyrrolidine-3-carboxylate;1-N-Boc-pyrrolidine-3-(S)-methylcarboxylate;(S)-1-BOC-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER;(S)-1-1-Boc-pyrrolidine-3-carboxylic acid methyl ester;(S)-1-tert-butyl 3-Methyl pyrrolidine-1,3-dicarboxylate;(R)-1-tert-butyl 3-methyl pyrrolidine-1,3-dicarboxylate
CBNumber
CB0970875
Molecular Formula
C11H19NO4
Formula Weight
229.27
MOL File
313706-15-9.mol
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(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester Property

Boiling point:
288.6±33.0 °C(Predicted)
Density 
1.120±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-2.65±0.40(Predicted)
Appearance
Colorless to light yellow Liquid
CAS DataBase Reference
313706-15-9
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B809983
Product name
(S)-1-tert-Butyl3-MethylPyrrolidine-1,3-dicarboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB151297
Product name
1-N-Boc-pyrrolidine-3-(S)-methylcarboxylate
Packaging
50mg
Price
$51
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-A4
Product name
Methyl (S)-1-Boc-pyrrolidine-3-carboxylate
Packaging
250mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-B0425
Product name
(S)-1-Boc-pyrrolidine-1,3-dicarboxylate
Purity
>97.0%
Packaging
250mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB151297
Product name
1-N-Boc-pyrrolidine-3-(S)-methylcarboxylate
Packaging
100mg
Price
$89
Updated
2021/12/16
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(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester Chemical Properties,Usage,Production

Synthesis

140148-70-5

74-88-4

313706-15-9

To a solution of (S)-1-BOC-pyrrolidine-3-carboxylic acid (863 mg, 4.01 mmol) and K2CO3 (829 mg, 6.00 mmol) in anhydrous DMF (8 mL) was added iodomethane (300 μL, 4.82 mmol). The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, water was added and extracted three times with ether (Et2O). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography (eluent: n-hexane/ethyl acetate = 3:1) to afford the target product (S)-1-Boc-3-carboxypyrrolidinium methyl ester (916 mg, 100%) as a colorless oil. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.70 (3H, s), 3.65-3.28 (4H, m), 3.10-2.98 (1H, m), 2.18-2.05 (2H, m), 1.45 (9H, s). lRMS (ESI, [M + Na]+) showed the molecular ion peak as 252.1.

References

[1] Tetrahedron, 2012, vol. 68, # 23, p. 4418 - 4428
[2] Patent: WO2013/25733, 2013, A1. Location in patent: Paragraph 0769
[3] Patent: WO2016/112088, 2016, A1. Location in patent: Paragraph 0749

(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester Suppliers

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