(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 138108-72-2
Chemical Name: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: (R)-1-Boc-3-pyrrolidineMethanol;N-Boc-D-^b-prolinol;N-Boc-D-beta-prolinol;N-Boc-D-^b-prolinol, 97+%;(R)-1-Boc-3-(hydroxyMethy...;(R)-N-BOC-PYRROLIDINE-3-METHANOL;[R]-1-BOC-3-Pyrrolidinemethanol 97%;(R)-1-Boc-3-hydroxymethylpyrrolidine;1-Boc-3(R)-(HydroxyMethyl)Pyrrolidine;(3R)-1-Boc-3-(hydroxymethyl)pyrrolidine
CBNumber: CB1668944
Molecular Formula: C10H19NO3
Formula Weight: 201.26
MOL File: 138108-72-2.mol

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(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 289.5±13.0 °C(Predicted)
Density: 1.089
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Oil
pka: 14.93±0.10(Predicted)
color: Clear Colourless to Pale Yellow
optical activity: Consistent with structure
Water Solubility: Slightly soluble in water
InChI: InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1
InChIKey: HKIGXXRMJFUUKV-MRVPVSSYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC[C@@H](CO)C1
CAS DataBase Reference: 138108-72-2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B665860
Product name: (R)-N-Boc-pyrrolidine-3-methanol
Packaging: 5g
Price: $965
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0017833
Product name: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $984.06
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0017833
Product name: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 5G
Price: $1848
Updated: 2021/12/16

AK Scientific

Product number: W3008
Product name: (R)-3-Hydroxymethylpyrrolidine-1-carboxylicacidtert-butylester
Packaging: 5g
Price: $151
Updated: 2021/12/16

Matrix Scientific

Product number: 072722
Product name: (R)-3-Hydroxymethylpyrrolidine-1-carboxylic acid tert-butyl ester
Purity: 95+%
Packaging: 1g
Price: $153
Updated: 2021/12/16

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(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Synthesis

72925-16-7

138108-72-2

Borane-THF complex (1.0 M, 17 mL, 16.9 mmol) was added slowly and dropwise to a stirred solution of (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (1.21 g, 5.6 mmol) in tetrahydrofuran (THF, 30 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature over 30 minutes, followed by heating at 45 °C for 1 hour and then at 55 °C for 90 minutes. Upon completion of the reaction, the mixture was cooled to 0 °C and quenched by careful addition of 3N hydrochloric acid (30 mL). After stirring for 20 min at room temperature, the reaction mixture was extracted with ether (Et2O, 50 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3, 20 mL) and brine (20 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to afford (R)-tert-butyl-3-(hydroxymethyl)pyrrolidine-1-carboxylate (1.1 g, 91% yield) as a colorless oil.

References

[1] Patent: WO2011/150198, 2011, A1. Location in patent: Page/Page column 151
[2] Patent: WO2010/45212, 2010, A2. Location in patent: Page/Page column 299
[3] Patent: US2013/184313, 2013, A1. Location in patent: Paragraph 1541

(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 159 India 3 United Kingdom 2 United States 20 Global 184

ITIC MEDCHEM(SUZHOU) CO.,LTD.

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View Lastest Price from (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 138108-72-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Career Henan Chemical Co

Product: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 138108-72-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 200KG
Release date: 2018-08-19

Career Henan Chemical Co

Product: (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 138108-72-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

138108-72-2, (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

(R)-N-Boc-3-aminomethylpiperidine 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid 2-(N,N-DIMETHYLAMINOMETHYL)PHENYLBORONIC ACID BOC-L-Prolinol (R)-2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3(S)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER,(S)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BOC-(TRANS)-4-(4-PYRIDINYL)-PYRROLIDINE-3-CARBOXYLIC ACID BOC-L-TRANSPRO(4-CH2OH) 1-[(TERT-BUTYL)OXYCARBONYL]-4-PHENYLPYRROLINE-3-CARBOXYLIC ACID BOC-(TRANS)-4-(2-FLUORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID BOC-(TRANS)-4-(4-FLUORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID (3S,4S)-4-BENZYL-1-(TERT-BUTOXYCARBONYL)PYRROLIDINE-3-CARBOXYLIC ACID BOC-(TRANS)-4-(2-METHYL-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID 1-[(TERT-BUTYL)OXYCARBONYL]-4-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE-3-CARBOXYLIC ACID

3(R)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-1-Boc-3-hydroxymethylpyrrolidine

(R)-1-tert-Butoxycarbonylpyrrolidine-3-methanol

(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-N-BOC-PYRROLIDINE-3-METHANOL

(3R)-3-(Hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

tert-butyl (3R)-3-(hydroxyMethyl)pyrrolidine-1-carboxylate

N-Boc-D-^b-prolinol, 97+%

1-Boc-3(R)-(HydroxyMethyl)Pyrrolidine

(R)-1-Boc-3-(hydroxyMethy...

(R)-1-Boc-3-pyrrolidineMethanol

(R)-3-hydroxyMethyl-pyrrolidine-1-carboxylic

(3R)-N-tert-butyloxycarbonyl-3-hydroxymethylpyrrolidine

1-Pyrrolidinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-

N-Boc-D-^b-prolinol

tert-butyl(R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

N-Boc-D-beta-prolinol

(3R)-1-Boc-3-(hydroxymethyl)pyrrolidine

[R]-1-BOC-3-Pyrrolidinemethanol 97%

(R)-3-hydroxymethyl-pyrrolidine-1-carboxylic acid Tert-Butyl...

1,1-Dimethylethyl (3R)-3-(hydroxymethyl)-1-pyrrolidinecarboxylate

138108-72-2

Heterocycle-other series

pharmacetical