1-Boc-3-hydroxymethylpyrrolidine

Product Name: 1-Boc-3-hydroxymethylpyrrolidine
CAS No.: 114214-69-6
Chemical Name: 1-Boc-3-hydroxymethylpyrrolidine
Synonyms: N-Boc-DL-beta-prolinol;N-Boc-DL-^b-prolinol, 97+%;1-Boc-3-(hydroxyMethyl)py...;N-Boc-DL-beta-prolinol, 97+%;1-BOC-3-Pyrrolidinemethanol 97%;1-BOC-3-HYDROXYMETHYLPYRROLIDINE;N-BOC--3-hydrozyMethyl-pyrroidine;3-HYDROXYMETHYL-1-BOC-PYRROLIDINE;N-Boc-3-(hydroxymethyl)pyrrolidine;1-BOC-3-Hydroxymethyl-1H-pyrrolidine
CBNumber: CB2737227
Molecular Formula: C10H19NO3
Formula Weight: 201.26
MOL File: 114214-69-6.mol

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1-Boc-3-hydroxymethylpyrrolidine Property

Boiling point:: 285-291℃
Density: 1.089
refractive index: 1.4680 to 1.4720
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: clear liquid
pka: 14.93±0.10(Predicted)
color: Colorless to Light orange to Yellow
InChI: InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3
InChIKey: HKIGXXRMJFUUKV-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(CO)C1
CAS DataBase Reference: 114214-69-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N,T
Risk Statements: 25-50
Safety Statements: 24/25-61-45
RIDADR: 2811
WGK Germany: 3
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000016
Product name: 3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TCI Chemical

Product number: B4249
Product name: 1-(tert-Butoxycarbonyl)-3-pyrrolidinemethanol
Purity: >95.0%(GC)
Packaging: 1g
Price: $124
Updated: 2025/07/31

TCI Chemical

Product number: B4249
Product name: 1-(tert-Butoxycarbonyl)-3-pyrrolidinemethanol
Purity: >95.0%(GC)
Packaging: 5g
Price: $369
Updated: 2025/07/31

TRC

Product number: B656678
Product name: 1-Boc-3-hydroxymethylpyrrolidine
Packaging: 1g
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 228681
Product name: 1-Boc-3-hydroxymethylpyrrolidine
Packaging: 250mg
Price: $200
Updated: 2021/12/16

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1-Boc-3-hydroxymethylpyrrolidine Chemical Properties,Usage,Production

Uses

1-Boc-3-hydroxymethylpyrrolidine is an intermediate of SR 9009 (S684255). SR 9009 is a synthetic REV-ERB agonist that regulates circadian behavior and metabolism; has potential use in the treatment of sleep disorders and metabolic diseases.

Synthesis

85310-69-6

24424-99-5

114214-69-6

General procedure for the synthesis of 1-Boc-3-hydroxymethylpyrrolidine from 3-pyrrolidine methanol and di-tert-butyl dicarbonate: 900 g of 3-pyrrolidine methanol was dissolved in 4.5 L of dichloromethane, and 900 g of di-tert-butyl dicarbonate and 1.8 kg of triethylamine were added in slow batch. The reaction mixture was stirred at room temperature for about 5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water. The product 1-Boc-3-hydroxymethylpyrrolidine was isolated and purified by conventional post-treatment methods in 95% yield.

References

[1] Patent: CN106588738, 2017, A. Location in patent: Paragraph 0035; 0037; 0040; 0045
[2] Synlett, 2017, vol. 28, # 4, p. 425 - 428
[3] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 13, p. 1785 - 1789
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 21, p. 3235 - 3238
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 1151 - 1175

1-Boc-3-hydroxymethylpyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-hydroxymethylpyrrolidine Suppliers

Americas 1 Belgium 2 China 173 Europe 1 France 3 Germany 5 India 5 Japan 1 The Netherlands 1 United Kingdom 5 United States 48 Global 245

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View Lastest Price from 1-Boc-3-hydroxymethylpyrrolidine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-Boc-3-hydroxymethylpyrrolidine 114214-69-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-06

Career Henan Chemical Co

Product: 1-Boc-3-hydroxymethylpyrrolidine 114214-69-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

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