Boc-D-prolinol
- Product Name
- Boc-D-prolinol
- CAS No.
- 83435-58-9
- Chemical Name
- Boc-D-prolinol
- Synonyms
- )-pyrroL;BOC-D-PRO-OL;BOC-D-PROLINOL;Boc-D-Proninol;N-BOC-D-PROLINOL;idine-1-carboxyL;1-BOC-D-PROLINOL;N-T-BOC-D-PROLINOL;N-benzyl-D-prolino;N-BENZYL-D-PROLINOL
- CBNumber
- CB5265945
- Molecular Formula
- C10H19NO3
- Formula Weight
- 201.26
- MOL File
- 83435-58-9.mol
Boc-D-prolinol Property
- Melting point:
- 60-64 °C (lit.)
- alpha
- 49 º (589nm, =1.3, CHCl3)
- Boiling point:
- 289.5±13.0 °C(Predicted)
- Density
- 1.084±0.06 g/cm3(Predicted)
- refractive index
- 54 ° (C=5, MeOH)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 14.77±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to light beige
- optical activity
- [α]23/D +50°, c = 1.3 in chloroform
- Water Solubility
- insoluble
- InChI
- InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1
- InChIKey
- BFFLLBPMZCIGRM-MRVPVSSYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC[C@@H]1CO
- CAS DataBase Reference
- 83435-58-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 29051990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 469440
- Product name
- (R)-(+)-1-Boc-2-pyrrolidinemethanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/01/07
- Product number
- B3076
- Product name
- N-(tert-Butoxycarbonyl)-D-prolinol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $19
- Updated
- 2025/07/31
- Product number
- B3076
- Product name
- N-(tert-Butoxycarbonyl)-D-prolinol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- B689475
- Product name
- N-(tert-Butoxycarbonyl)-D-prolinol
- Packaging
- 100g
- Price
- $545
- Updated
- 2021/12/16
- Product number
- P000485679
- Product name
- Boc-D-Prolinol
- Purity
- 97%
- Packaging
- 5g
- Price
- $12
- Updated
- 2021/12/16
Boc-D-prolinol Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
N-(tert-Butoxycarbonyl)-D-prolinol is used to prepare (azetidinyl)methoxy]pyridines and 2-(aryloxymethyl) azacyclic analogs with therapeutic potetials for the treatment of central nervous system (CNS) disorders.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
68832-13-3
24424-99-5
59378-81-3
Step 1: Dissolve (R)-2-(hydroxymethyl)pyrrolidine (2.0 g, 19.8 mmol) in dichloromethane (20 mL) and add 1 M aqueous sodium hydroxide solution (20 mL). A solution of di-tert-butyl dicarbonate (4.32 g, 19.8 mmol) in dichloromethane (10 mL) was added slowly and dropwise at room temperature. The reaction mixture was stirred at room temperature for 5 hours. After completion of the reaction, the organic and aqueous layers were separated. The organic layer was washed twice with distilled water and the aqueous layer was extracted with dichloromethane. All organic layers were combined and dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. Purification by recrystallization from hexane afforded the intermediate (R)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate in a yield of 2.60 g (65% yield).
References
[1] Patent: US5902819, 1999, A
[2] Patent: WO2006/19833, 2006, A1. Location in patent: Page/Page column 60
[3] European Journal of Organic Chemistry, 2002, # 14, p. 2391 - 2399
[4] Tetrahedron Letters, 1997, vol. 38, # 37, p. 6479 - 6482
[5] Tetrahedron Asymmetry, 1997, vol. 8, # 13, p. 2209 - 2213
Boc-D-prolinol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Boc-D-prolinol manufacturers
- Product
- Boc-D-prolinol 83435-58-9
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kgs
- Release date
- 2021-08-27
- Product
- Boc-D-Pro-Ol 83435-58-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-01-18
- Product
- Boc-D-prolinol 83435-58-9
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-21