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Boc-D-prolinol

Product Name
Boc-D-prolinol
CAS No.
83435-58-9
Chemical Name
Boc-D-prolinol
Synonyms
)-pyrroL;BOC-D-PRO-OL;BOC-D-PROLINOL;Boc-D-Proninol;N-BOC-D-PROLINOL;idine-1-carboxyL;1-BOC-D-PROLINOL;N-T-BOC-D-PROLINOL;N-benzyl-D-prolino;N-BENZYL-D-PROLINOL
CBNumber
CB5265945
Molecular Formula
C10H19NO3
Formula Weight
201.26
MOL File
83435-58-9.mol
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Boc-D-prolinol Property

Melting point:
60-64 °C (lit.)
alpha 
49 º (589nm, =1.3, CHCl3)
Boiling point:
289.5±13.0 °C(Predicted)
Density 
1.084±0.06 g/cm3(Predicted)
refractive index 
54 ° (C=5, MeOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
14.77±0.10(Predicted)
form 
Crystalline Powder
color 
White to light beige
optical activity
[α]23/D +50°, c = 1.3 in chloroform
Water Solubility 
insoluble
InChI
InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1
InChIKey
BFFLLBPMZCIGRM-MRVPVSSYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC[C@@H]1CO
CAS DataBase Reference
83435-58-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29051990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
469440
Product name
(R)-(+)-1-Boc-2-pyrrolidinemethanol
Purity
98%
Packaging
1g
Price
$25
Updated
2023/01/07
TCI Chemical
Product number
B3076
Product name
N-(tert-Butoxycarbonyl)-D-prolinol
Purity
>98.0%(GC)
Packaging
1g
Price
$19
Updated
2025/07/31
TCI Chemical
Product number
B3076
Product name
N-(tert-Butoxycarbonyl)-D-prolinol
Purity
>98.0%(GC)
Packaging
5g
Price
$53
Updated
2025/07/31
TRC
Product number
B689475
Product name
N-(tert-Butoxycarbonyl)-D-prolinol
Packaging
100g
Price
$545
Updated
2021/12/16
Ark Pharm
Product number
P000485679
Product name
Boc-D-Prolinol
Purity
97%
Packaging
5g
Price
$12
Updated
2021/12/16
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Boc-D-prolinol Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-(tert-Butoxycarbonyl)-D-prolinol is used to prepare (azetidinyl)methoxy]pyridines and 2-(aryloxymethyl) azacyclic analogs with therapeutic potetials for the treatment of central nervous system (CNS) disorders.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

68832-13-3

24424-99-5

59378-81-3

Step 1: Dissolve (R)-2-(hydroxymethyl)pyrrolidine (2.0 g, 19.8 mmol) in dichloromethane (20 mL) and add 1 M aqueous sodium hydroxide solution (20 mL). A solution of di-tert-butyl dicarbonate (4.32 g, 19.8 mmol) in dichloromethane (10 mL) was added slowly and dropwise at room temperature. The reaction mixture was stirred at room temperature for 5 hours. After completion of the reaction, the organic and aqueous layers were separated. The organic layer was washed twice with distilled water and the aqueous layer was extracted with dichloromethane. All organic layers were combined and dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. Purification by recrystallization from hexane afforded the intermediate (R)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate in a yield of 2.60 g (65% yield).

References

[1] Patent: US5902819, 1999, A
[2] Patent: WO2006/19833, 2006, A1. Location in patent: Page/Page column 60
[3] European Journal of Organic Chemistry, 2002, # 14, p. 2391 - 2399
[4] Tetrahedron Letters, 1997, vol. 38, # 37, p. 6479 - 6482
[5] Tetrahedron Asymmetry, 1997, vol. 8, # 13, p. 2209 - 2213

Boc-D-prolinol Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-D-prolinol Suppliers

Americas 1 Belgium 1 Canada 1 China 296 Europe 1 Germany 3 India 10 Italy 2 Japan 6 South Korea 1 Switzerland 2 United Kingdom 11 United States 42 Global 377
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from Boc-D-prolinol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-D-prolinol 83435-58-9
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-08-27
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-D-Pro-Ol 83435-58-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-18
Hebei Chuanghai Biotechnology Co,.LTD
Product
Boc-D-prolinol 83435-58-9
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-21

83435-58-9, Boc-D-prolinolRelated Search:

Hydrogenated Cottonseed Oil N-Methyl-2-pyrrolidone Dexketoprofen trometamol Pyrrolidine Polyvinylpyrrolidone phytosphingosine Ketorolac tromethamine Fosfomycin tromethamine D(-)Prolinol N-Vinyl-2-pyrrolidone BOC-L-Prolinol METHYL-2-PYRROLIDONE 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BOC-L-PROLINOL LIQUID Boc-D-prolinol tert-Butoxide

  • BOC-D-PRO-OL
  • BOC-D-PROLINOL
  • BOC-(R)-2-(HYDROXYMETHYL) PYRROLIDINE
  • N-TERT-BUTOXYCARBONYL-D-PROLINOL
  • N-T-BUTOXYCARBONYL-D-PROLINOL
  • N-T-BOC-D-PROLINOL
  • N-BOC-D-PROLINOL
  • N-ALPHA-T-BOC-D-PROLINOL
  • (R)-2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • (R)-(+)-1-BOC-2-PYRROLIDINEMETHANOL
  • (R)-1-BOC-2-PYRROLIDINEMETHANOL
  • (R)-(+)-1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINEMETHANOL
  • (R)-(-)-N-BOC-PROLINOL
  • (R)-N-TERT-BUTOXYCARBONYL PROLINOL
  • (R)-1-Boc-2-(hydroxyMethyl)pyrrolidine
  • tert-butyl (R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
  • tert-butyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
  • (R)-Boc-2-pyrrolidinemethanol
  • Boc-D-Prolinol≥ 98% (HPLC)
  • N-Boc-D-prolinol,99%e.e.
  • N-BENZYL-D-PROLINOL
  • 1-BOC-D-PROLINOL
  • 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R)-
  • N-tert-Butoxycarbonyl-D-prolino
  • N-alpha-t-Butyloxycarbonyl-D-prolinol, (R)-N-t-Butyloxycarbonyl-2-pyrrolidinemethanol
  • BOC-D-PROLINOL LIQUID
  • N-t-Boc-D-prolinol, N-Boc-D-prolinol, (R)-(+)-1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol
  • N-tert-Butoxycarbonyl-D-prolinol,98%
  • (R)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate
  • N-Boc-D-prolinol,(R)-1-Boc-2-pyrrolidinemethanol
  • (R)-(+)-1-Boc-2-pyrrolidinemethanol,(R)-(+)-1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol, N-t-Boc-D-prolinol, N-Boc-D-prolinol
  • N-Boc-D-prolinol (R)-1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol (R)-1-Boc-2-pyrrolidinemethanol
  • Boc-D-prolinol/(R)-(+)-1-(tert-Butoxycarbonyl)-2-pyrrolidineMethanol
  • (3R)-2-(Hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester
  • Boc-D-Proninol
  • N-(tert-Butoxycarbonyl)-D-prolinol &gt
  • idine-1-carboxyL
  • )-pyrroL
  • Boc-D-prolinol USP/EP/BP
  • 1,1-Dimethylethyl (2R)-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
  • N-Boc-D-prolinol,97%
  • (<i>R</i>)-(+)-1-Boc-2-pyrrolidinemethanol
  • N-benzyl-D-prolino
  • 83435-58-9
  • Specialty Synthesis
  • Peptide Synthesis
  • Amino Alcohols
  • Amino Acid Derivatives
  • Chiral Building Blocks
  • Glycidyl Compounds, etc. (Chiral)
  • Synthetic Organic Chemistry
  • Chiral Products
  • Amino Acids
  • Alcohol Aldehyde & acid series