2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-

Product Name: 2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-
CAS No.: 2561494-77-5
Chemical Name: 2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-
Synonyms: UNC6934 ，E1059;UNC6934, 10 mM in DMSO;Inhibitor,UNC6934,Histone Methyltransferase,inhibit,UNC 6934,UNC-6934;N-Cyclopropyl-3-oxo-N-[4-(4-pyrimidinylcarbamoyl)benzyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide;N-Cyclopropyl-3-oxo-N-(4-(pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide;2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-
CBNumber: CB09966192
Molecular Formula: C24H21N5O4
Formula Weight: 443.46
MOL File: 2561494-77-5.mol

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2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Property

Boiling point:: 697.2±55.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: 10.91±0.70(Predicted)
color: Pale yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: KOZGEDUWAQFVAV-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(CN(C2CC2)C(C3=CC4=C(NC(CO4)=O)C=C3)=O)C=C1)NC5=CC=NC=N5

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2813
Product name: UNC6934
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $113.38
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2813
Product name: UNC6934
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $458.19
Updated: 2025/07/31

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2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Chemical Properties,Usage,Production

Description

UNC6934 (2561494-77-5) is a potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2).? It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2.? UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases.? Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 μM).

Uses

UNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization.

storage

Store at -20°C

References

[1] DAVID DILWORTH. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization[J]. Nature chemical biology, 2021, 18 1: 56-63. DOI:10.1038/s41589-021-00898-0

2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Suppliers

China 35 United States 3 Global 38

ShangHai Caerulum Pharma Discovery Co., Ltd.

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2561494-77-5, 2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-Related Search:

PF-01367338 RESINIFERATOXIN DO264 ML335

2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-

Inhibitor,UNC6934,Histone Methyltransferase,inhibit,UNC 6934,UNC-6934

N-Cyclopropyl-3-oxo-N-[4-(4-pyrimidinylcarbamoyl)benzyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide

UNC6934, 10 mM in DMSO

N-Cyclopropyl-3-oxo-N-(4-(pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide

UNC6934 ，E1059

2561494-77-5