2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Property

Boiling point:

697.2±55.0 °C(Predicted)

Density 

1.45±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO (>25 mg/ml)

pka

10.91±0.70(Predicted)

form 

solid

color 

Pale yellow

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Hazard and Precautionary Statements (GHS)

2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Chemical Properties,Usage,Production

Description

UNC6934 (2561494-77-5) is a potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2).? It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2.? UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases.? Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 μM).

storage

Store at -20°C

References

Dilworth et al. (2022), A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization; Nat. Chem. Biol., 18 56