ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE

Product Name: ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE
CAS No.: 329218-11-3
Chemical Name: ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE
Synonyms: Quetiapine EP Impurity S HCl Salt;Quetiapine S-oxide dihydrochloride;Quetiapine sulfoxide (dihydrochloride);Quetiapine EP Impurity S DiHCl (Quetiapine Sulfoxide DiHCl);QUETIAPINE SULFOXIDE DIHYDROCHLORIDE; QUETIAPINE S-OXIDE DIHYDROCHLORIDE;11-(4-(2-(2-Hydroxyethoxy)ethyl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepine 5-oxide dihydrochloride;ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE
CBNumber: CB11011224
Molecular Formula: C21H26ClN3O3S
Formula Weight: 435.97
MOL File: 329218-11-3.mol

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ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE Property

storage temp.: Store at -20°C
form: Solid
color: White to yellow
Water Solubility: Water: 250 mg/mL (529.18 mM)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5189
Product name: Quetiapinesulfoxide(dihydrochloride)
Purity: 98.94%
Packaging: 1mg
Price: $105
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0151829
Product name: ETHANOL-2-(2-(4-(5-OXIDODIBENZO(B,F)(1,4)THIAZEPIN-11-YL)-1-PIPERAZINYL)ETHOXY)-DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 2.5MG
Price: $704
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0151829
Product name: ETHANOL-2-(2-(4-(5-OXIDODIBENZO(B,F)(1,4)THIAZEPIN-11-YL)-1-PIPERAZINYL)ETHOXY)-DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 5G
Price: $874.45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0151829
Product name: ETHANOL-2-(2-(4-(5-OXIDODIBENZO(B,F)(1,4)THIAZEPIN-11-YL)-1-PIPERAZINYL)ETHOXY)-DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 25MG
Price: $1871.1
Updated: 2021/12/16

Crysdot

Product number: CD31002228
Product name: Quetiapinesulfoxidedihydrochloride
Purity: 98+%
Packaging: 5mg
Price: $126
Updated: 2021/12/16

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ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[2].

in vivo

The C_max value (mean±SD) is estimated for Quetiapine sulfoxide (77.3±32.4 ng/mL). The AUC_last value is estimated for Quetiapine sulfoxide (1,286±458 ng?h/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing^[1].

References

[1] Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537. DOI:10.1002/cpdd.290
[2] Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. DOI:10.1111/bph.13346

ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE Suppliers

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329218-11-3, ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDERelated Search:

Angeli’s Salt Lignosulfonic acid 11-(PIPERAZIN-1-YL)DIBENZO[B,F][1,4]THIAZEPINE 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 1-[2(2-Hydroxyethoxy)ethyl]piperazine dihydrochloride QUETIAPINE SULFOXIDE Quetiapine 11-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPIN HYDROCHLORIDE ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE

ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE

Quetiapine sulfoxide (dihydrochloride)

Quetiapine EP Impurity S DiHCl (Quetiapine Sulfoxide DiHCl)

Quetiapine EP Impurity S HCl Salt

Quetiapine S-oxide dihydrochloride

QUETIAPINE SULFOXIDE DIHYDROCHLORIDE; QUETIAPINE S-OXIDE DIHYDROCHLORIDE

11-(4-(2-(2-Hydroxyethoxy)ethyl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepine 5-oxide dihydrochloride

329218-11-3