ChemicalBook > CAS DataBase List > ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE

ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE

Product Name
ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE
CAS No.
329218-11-3
Chemical Name
ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE
Synonyms
Quetiapine EP Impurity S HCl Salt;Quetiapine S-oxide dihydrochloride;Quetiapine sulfoxide (dihydrochloride);Quetiapine EP Impurity S DiHCl (Quetiapine Sulfoxide DiHCl);QUETIAPINE SULFOXIDE DIHYDROCHLORIDE; QUETIAPINE S-OXIDE DIHYDROCHLORIDE;11-(4-(2-(2-Hydroxyethoxy)ethyl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepine 5-oxide dihydrochloride;ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE
CBNumber
CB11011224
Molecular Formula
C21H26ClN3O3S
Formula Weight
435.97
MOL File
329218-11-3.mol
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ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE Property

storage temp. 
Store at -20°C
form 
Solid
color 
White to yellow
Water Solubility 
Water: 250 mg/mL (529.18 mM)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5189
Product name
Quetiapinesulfoxide(dihydrochloride)
Purity
98.94%
Packaging
1mg
Price
$105
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0151829
Product name
ETHANOL-2-(2-(4-(5-OXIDODIBENZO(B,F)(1,4)THIAZEPIN-11-YL)-1-PIPERAZINYL)ETHOXY)-DIHYDROCHLORIDE
Purity
95.00%
Packaging
2.5MG
Price
$704
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0151829
Product name
ETHANOL-2-(2-(4-(5-OXIDODIBENZO(B,F)(1,4)THIAZEPIN-11-YL)-1-PIPERAZINYL)ETHOXY)-DIHYDROCHLORIDE
Purity
95.00%
Packaging
5G
Price
$874.45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0151829
Product name
ETHANOL-2-(2-(4-(5-OXIDODIBENZO(B,F)(1,4)THIAZEPIN-11-YL)-1-PIPERAZINYL)ETHOXY)-DIHYDROCHLORIDE
Purity
95.00%
Packaging
25MG
Price
$1871.1
Updated
2021/12/16
Crysdot
Product number
CD31002228
Product name
Quetiapinesulfoxidedihydrochloride
Purity
98+%
Packaging
50mg
Price
$910
Updated
2021/12/16
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ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[2].

in vivo

The Cmax value (mean±SD) is estimated for Quetiapine sulfoxide (77.3±32.4 ng/mL). The AUClast value is estimated for Quetiapine sulfoxide (1,286±458 ng?h/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing[1].

References

[1] Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537. DOI:10.1002/cpdd.290
[2] Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. DOI:10.1111/bph.13346

ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE Suppliers

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329218-11-3, ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDERelated Search:

Angeli’s Salt Lignosulfonic acid 11-(PIPERAZIN-1-YL)DIBENZO[B,F][1,4]THIAZEPINE 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 1-[2(2-Hydroxyethoxy)ethyl]piperazine dihydrochloride QUETIAPINE SULFOXIDE Quetiapine 11-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPIN HYDROCHLORIDE ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE

  • ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE
  • Quetiapine sulfoxide (dihydrochloride)
  • Quetiapine EP Impurity S DiHCl (Quetiapine Sulfoxide DiHCl)
  • Quetiapine EP Impurity S HCl Salt
  • Quetiapine S-oxide dihydrochloride
  • QUETIAPINE SULFOXIDE DIHYDROCHLORIDE; QUETIAPINE S-OXIDE DIHYDROCHLORIDE
  • 11-(4-(2-(2-Hydroxyethoxy)ethyl)piperazin-1-yl)dibenzo[b,f][1,4]thiazepine 5-oxide dihydrochloride
  • 329218-11-3