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Gepirone

Product Name
Gepirone
CAS No.
83928-76-1
Chemical Name
Gepirone
Synonyms
GEPIRONE;Gepirona;Gepironum;Gepirone er;Gepirone HCl;Gepirone [inn];Gepironum [latin];Gepirona [spanish];ORG-13011(Gepirone);Gepirone(ORG-13011)
CBNumber
CB11011279
Molecular Formula
C19H29N5O2
Formula Weight
359.47
MOL File
83928-76-1.mol
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Gepirone Property

Melting point:
106-108°C
Boiling point:
562.3±60.0 °C(Predicted)
Density 
1.142±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
7.72±0.10(Predicted)
color 
Off-White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
G365000
Product name
Gepirone
Packaging
250mg
Price
$845
Updated
2021/12/16
Matrix Scientific
Product number
099512
Product name
4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione
Purity
95%
Packaging
250mg
Price
$925
Updated
2021/12/16
AK Scientific
Product number
2913AC
Product name
4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione
Packaging
1g
Price
$1023
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO65115
Product name
Gepirone
Packaging
10mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO65115
Product name
Gepirone
Packaging
50mg
Price
$225
Updated
2021/12/16
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Gepirone Chemical Properties,Usage,Production

Description

Gepirone is a chemical analogue of buspirone and also acts as a partial agonist at 5-HT1A receptors. It is active in animal models predictive of anxiolytic action and also shows antidepressant activity in preclinical studies. With long-term administration, gepirone downregulates 5-HT2 receptors, which is a property common to nearly all antidepressant drugs (Stahl 1994). This dual action, suggesting both anxiolytic and antidepressant effects, is typical of many compounds acting at 5-HT1A receptors and may indicate that such compounds may be useful in the treatment of mixed anxiety and depression (Stahl, in press).
Preliminary phase II clinical data have shown that gepirone is an effective anxiolytic that significantly reduces both psychic and somatic symptoms of generalized anxiety disorder. Like buspirone, gepirone does not impair memory, verbal fluency, or psychomotor performance (Harto and Branconnier 1988).

Uses

Gepirone is an antidepressant and anxiolytic of the azapirone class. It acts as a selective partial agonist of the 5-HT1A receptor.

Definition

ChEBI: Gepirone is a N-arylpiperazine.

Gepirone Preparation Products And Raw materials

Raw materials

Preparation Products

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Gepirone Suppliers

BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80

83928-76-1, GepironeRelated Search:


  • GEPIRONE
  • 4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione
  • 4,4-Dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6-piperidinedione
  • 2,6-Piperidinedione, 4,4-dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-
  • 83928-66-9 (Mono-hydrochloride)
  • Gepirona
  • Gepirona [spanish]
  • Gepirone [inn]
  • Gepirone er
  • Gepironum
  • Gepironum [latin]
  • ORG-13011(Gepirone)
  • Gepirone(ORG-13011)
  • Gepirone HCl
  • 83928-76-1
  • C19H29N5O2
  • API