TETRAMETHYLTIN Property

Melting point:

−54 °C(lit.)

Boiling point:

74-75 °C(lit.)

Density 

1.291 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.441(lit.)

Flash point:

9 °F

storage temp. 

Store below +30°C.

form 

liquid

Specific Gravity

1.291

color 

colorless

Water Solubility 

Insoluble in water. Soluble in organic solvents

Hydrolytic Sensitivity

1: no significant reaction with aqueous systems

BRN 

3647887

CAS DataBase Reference

594-27-4(CAS DataBase Reference)

EPA Substance Registry System

Stannane, tetramethyl- (594-27-4)

Safety

Hazard Codes 

T+,N

Risk Statements 

26/27/28-50/53

Safety Statements 

26-27-28-45-60-61

RIDADR 

UN 3384 6.1/PG 1

WGK Germany 

2

RTECS 

WH8630000

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29310099

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

TETRAMETHYLTIN Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

Tetramethyltin is used in many organic syntheticreactions.

Uses

Tetramethylstannane is used in preparation of Biphenyl Pyrazines as PD-1/PD-L1 inhibitors for treating cancer.

Definition

ChEBI: An organotin compound carrying four methyl groups.

Health Hazard

Tetramethyltin is moderately toxic by allroutes of exposure. The symptoms includeheadache, muscle weakness, and paralysis.Exposure limits:
TLV-TWA: 0.1 mg (Sn)/m³ (skin) (ACGIH)
PEL-TWA: 0.1 mg (Sn)/m³ (skin) (OSHA).

Fire Hazard

The ease of oxidation, however, is low in comparison with most other metal alkyls. It is relatively stable to air and does not ignite spontaneously as other alkyls do. Also, it is stable in water. The compound, however, is highly flammable, the flash point being ( －13°C) 9°F (Aldrich 1996). It explodes violently in contact with dinitrogen tetraoxide even, at －80°C (－112°F) (Bailar 1973). Reaction with strong oxidizers is expected to be vigorous to violent.

Safety Profile

Moderately toxic by inhalation. A very dangerous fire and explosion hazard when exposed to heat, flame, or oxidizers. Powerful explosive reaction with dinitrogen tetroxide. To fight fire, use water, foam, CO2, dry chemical. When heated it emits acrid smoke and irritating fumes. See also TIN COMPOUNDS and ORGANOMETALS.

Purification Methods

It is purified by fractionation using a Todd column (p 11) of 35-40 plates at atmospheric pressure. The purity of the fractions can be followed by IR [Edgell & Ward J Am Chem Soc 77 6486 1955]. It readily dissolves stopcock silicone greases which give bands in the 8-10a region. [Edgell & Ward J Am Chem Soc 76 1169 1954, Beilstein 4 IV 4307.]