Livmoniplimab

Product Name: Livmoniplimab
CAS No.: 2412004-88-5
Chemical Name: Livmoniplimab
Synonyms: Livmoniplimab;Research Grade Livmoniplimab;Research Grade Livmoniplimab (DHB91603)
CBNumber: CB110617099
Formula Weight: 0
MOL File: Mol file

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Livmoniplimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Livmoniplimab Chemical Properties,Usage,Production

Uses

Livmoniplimab (ABBV-151) is a monoclonal antibody against GARP/TGF-β1 that can inhibit the release of active TGF-β1. Livmoniplimab has anti-tumor activity in colon cancer mice. Livmoniplimab can be used for the study of locally advanced or metastatic solid tumors[1][2].

in vivo

Livmoniplimab (250 μg; three times a week; 3 weeks; i.p.) exhibits anti-tumor activity in colon cancer mice^[2].

Animal Model:	7-week-old female B-hGARP mice subcutaneously inoculated with MC38 mouse colon cancer cells^[2].
Dosage:	250 μg
Administration:	Intraperitoneal injection (i.p.); three times a week; 3 weeks
Result:	Resulted in 34.3% tumor growth inhibition.

References

[1] Tindall RR, et al. The TGF-β superfamily as potential therapeutic targets in pancreatic cancer. Front Oncol. 2024 Mar 4;14:1362247. DOI:10.3389/fonc.2024.1362247
[2] Guo J, et al. A novel GARP humanized mouse model for efficacy assessment of GARP-targeting therapies. Int Immunopharmacol. 2024 Mar 30;130:111782. DOI:10.1016/j.intimp.2024.111782

Livmoniplimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Livmoniplimab Suppliers

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Livmoniplimab

Research Grade Livmoniplimab (DHB91603)

Research Grade Livmoniplimab

2412004-88-5