Placulumab

Product Name: Placulumab
CAS No.: 945781-29-3
Chemical Name: Placulumab
Synonyms: Placulumab;Research Grade Placulumab
CBNumber: CB28080866
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Placulumab Chemical Properties,Usage,Production

Uses

Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis[1].

in vivo

Placulumab (0.3, 1, 3 and 10 mg/kg; i.p.; twice weekly for 8 weeks) has effective anti-arthritis properties in Tg197 transgenic mouse model^[1].
Pharmacokinetic (PK) parameters of Placulumab in cynomolgus macaques^[1]

Route	Dose (mg/kg)	Exposure AUC_{0-336 h} (ng.h/mL)	Maximum concentration C_max (ng/mL)	Time of maximum concentration t_max (h)	Elimination half-life t_1/2 (h)	Clearance C_L (mL/hr/kg)
Intravenous injection (Males)	50	46000000	1320000	0.167	104	0.985
Intravenous injection (Females)	50	43300000	1020000	0.211	97.4	1.06
Route	Dose (mg/kg)	Exposure AUC_{0-336 h} (ng.h/mL)	Dose normalize exposure AUC_{0-336 h} (norm)	Maximum concentration C_max (ng/mL)	Time of maximum concentration t_max (h)	Elimination half-life t_1/2 (h)
Subcutaneous injection (Males)	0.5	676000	1350000	3190	50.0	120
Subcutaneous injection (Females)	0.5	445000	890000	2880	48.0	108
Subcutaneous injection (Males)	5	3940000	788000	22700	40.0	117
Subcutaneous injection (Females)	5	3840000	767000	23800	12.0	109
Subcutaneous injection (Males)	50	41600000	832000	272000	40.0	122
Subcutaneous injection (Females)	50	32300000	646000	212000	32.0	107

References

[1] Gay RD, et al. Anti-TNFα domain antibody construct CEP-37247: Full antibody functionality at half the size. MAbs. 2010 Nov-Dec;2(6):625-38. DOI:10.4161/mabs.2.6.13493

Placulumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Placulumab Suppliers

China 9 Global 9

Wuhan Chemstan Biotechnology Co., Ltd.

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Placulumab

Research Grade Placulumab

945781-29-3