ChemicalBook > CAS DataBase List > Geptanolimab
Geptanolimab
- Product Name
- Geptanolimab
- CAS No.
- 2348469-43-0
- Chemical Name
- Geptanolimab
- Synonyms
- Geptanolimab;Geptanolimab (anti-PDCD1);Research Grade Geptanolimab;Research Grade Geptanolimab (DHH02224)
- CBNumber
- CB310617013
- Formula Weight
- 0
- MOL File
- Mol file
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Geptanolimab Property
- form
- Liquid
- color
- Colorless to light yellow
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Geptanolimab Chemical Properties,Usage,Production
Uses
Geptanolimab (CBT-501) is a humanized IgG4k monoclonal antibody against programmed death-1 (PD-1). Siplizumab inhibits the binding of PD-L1/L2 to PD-1 through a competitive action. Siplizumab can be used in research of cancer[1].
in vivo
Geptanolimab (ip; once every two weeks, for 6 weeks; mice with MC38 syngeneic tumor models) has anti-tumor activity and tumor inhibition rate reached 83%[1].
References
[1] Qing Z, et, al. Activity of CBT-501, a novel humanized anti-PD-1 antibody, in a humanized genetically engineered mouse model of colon carcinoma. Journal of Clinical Oncology. 2017;35 (7_suppl):108-108.
Geptanolimab Preparation Products And Raw materials
Raw materials
Preparation Products
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