ChemicalBook > CAS DataBase List > Lesofavumab
Lesofavumab
- Product Name
- Lesofavumab
- CAS No.
- 1807960-57-1
- Chemical Name
- Lesofavumab
- Synonyms
- Lesofavumab;Research Grade Lesofavumab;Research Grade Lesofavumab (DVV03805)
- CBNumber
- CB98081024
- Formula Weight
- 0
- MOL File
- Mol file
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Lesofavumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Lesofavumab Chemical Properties,Usage,Production
Uses
Lesofavumab (MHAB5553A) is a human IgG1κ anti-influenza B virus antibody[1].
in vivo
Lesofavumab (46B8; 15 mg/kg; i.v.; single dose) is able to protect mice against lethal challenge of the mutant influenza B virus[2].
| Animal Model: | DBA/2?J mice, B/Wisconsin/1/2010, B/Brisbane/60/2008, B/Victoria/504/2000, B/Russia/1/1969 or B/Massachusetts/3/1966 infection model[2] |
| Dosage: | 15 mg/kg |
| Administration: | Intravenous administration, single dose, 24, 48 or 72?h post infection |
| Result: | Treatment at 24 and 48 h post infection resulted in 100% protection, with the only exception of mice infected with B/Russia/1/1969 that showed a 60% protection when treatment commenced at 48?h. Even when given at 72?h post infection, 48B8 was highly efficacious resulting in 100% protection against the B/Brisbane/60/2008, B/Victoria/504/2000 and B/Massachusetts/3/1966 strains, 75% protection against B/Wisconsin/1/2010 and 50% protection against B/Russia/1/1969. |
References
[1] Rao GK, et al. In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection. Toxicol Sci. 2019 Jun 1;169(2):409-421. DOI:10.1093/toxsci/kfz053
[2] Chai N, et al. A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action. Nat Commun. 2017 Jan 19;8:14234. DOI:10.1038/ncomms14234
Lesofavumab Preparation Products And Raw materials
Raw materials
Preparation Products
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