Envafolimab
- Product Name
- Envafolimab
- CAS No.
- 2102192-68-5
- Chemical Name
- Envafolimab
- Synonyms
- Envafolimab;Envafolimab (anti-PD-L1);Research Grade Envafolimab;Research Grade Envafolimab (DHJ70104)
- CBNumber
- CB48081155
- Formula Weight
- 0
- MOL File
- Mol file
Envafolimab Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
Envafolimab Chemical Properties,Usage,Production
Uses
Envafolimab (ASC 22; KN 035) is a recombinant protein of a humanized single-domain anti- PD-L1 antibody. Envafolimab is created by a fusion of the of anti-PD-L1 domain with Fc fragment of human IgG1 antibody. Envafolimab blocks interaction between PD-L1 and PD-1 with an IC50 value of 5.25?nM. Envafolimab has the potential for the research of solid tumors[1][2][3].
in vivo
Envafolimab (0.18-0.92 mg/kg; i.p.; four times over 2 weeks) shows antitumor activity with a half-life of ~72?h in NOD-SCID mice (A375 cells)[3].
References
[1] Papadopoulos KP, et al. First-in-Human Phase I Study of Envafolimab, a Novel Subcutaneous Single-Domain Anti-PD-L1 Antibody, in Patients with Advanced Solid Tumors. Oncologist. 2021 Sep;26(9):e1514-e1525. DOI:10.1002/onco.13817
[2] Akinleye A, et al. Immune checkpoint inhibitors of PD-L1 as cancer therapeutics. J Hematol Oncol. 2019 Sep 5;12(1):92. DOI:10.1186/s13045-019-0779-5
[3] Zhang F, Wei H, Wang X, Bai Y, Wang P, Wu J, Jiang X, Wang Y, Cai H, Xu T, Zhou A. Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade. Cell Discov. 2017 Mar 7;3:17004. DOI:10.1038/celldisc.2017.4
Envafolimab Preparation Products And Raw materials
Raw materials
Preparation Products
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