Ubamatamab

Product Name: Ubamatamab
CAS No.: 2305629-50-7
Chemical Name: Ubamatamab
Synonyms: Ubamatamab;Research Grade Ubamatamab;Research Grade Ubamatamab (DHJ31005)
CBNumber: CB510617077
Formula Weight: 0
MOL File: Mol file

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Ubamatamab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Ubamatamab Chemical Properties,Usage,Production

Uses

Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity[1].

in vivo

Ubamatamab (REGN4018; 0.01-0.5 mg/kg; i.p; on days 6, 10, 13, 16, and 21) potently inhibits growth of intraperitoneal ovarian tumors^[1].
Ubamatamab (REGN4018; 0.01-1 mg/kg; i.p; once a week; total of five doses) shows minimal and transient increases in serum cytokines and C-reactive protein, with no overt toxicity^[1].

Animal Model:	NOD SCID gamma (NSG) mice injected with OVCAR-3/Luc cells^[1]
Dosage:	0.01 mg/kg, 0.1 mg/kg, 0.5 mg/kg
Administration:	i.p; on days 6, 10, 13, 16, and 21
Result:	Significantly reduced tumor burden, and did not result in any changes in weight.

Animal Model:	Cynomolgus monkeys
Dosage:	0.01, 0.1, or 1 mg/kg
Administration:	i.p; once a week; total of five doses
Result:	Showed minimal and transient increases in serum cytokines and C-reactive protein.

References

[1] Alison Crawford, et al. A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer. Sci Transl Med. 2019 Jun 19;11(497):eaau7534. DOI:10.1126/scitranslmed.aau7534

Ubamatamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Ubamatamab Suppliers

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Ubamatamab

Research Grade Ubamatamab (DHJ31005)

Research Grade Ubamatamab

2305629-50-7