Vanucizumab

Product Name: Vanucizumab
CAS No.: 1448221-05-3
Chemical Name: Vanucizumab
Synonyms: Vanucizumab;Research Grade Vanucizumab;Research Grade Vanucizumab (DHA42302)
CBNumber: CB68080910
Formula Weight: 0
MOL File: Mol file

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Vanucizumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Vanucizumab Chemical Properties,Usage,Production

Uses

Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and angiopoietin-2 (Ang-2) from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects[1].

in vivo

Vanucizumab (20 mg/kg; i.p.; once weekly; for 6 weeks) shows tumor growth inhibition and induces tumor stasis^[2].

Animal Model:	SCID beige mice bearing Colo205 cells^[2]
Dosage:	20 mg/kg
Administration:	i.p.; once weekly; for 6 weeks
Result:	Showed tumor growth inhibition.

References

[1] Manuel Hidalgo, et al. First-in-Human Phase I Study of Single-agent Vanucizumab, A First-in-Class Bispecific Anti-Angiopoietin-2/Anti-VEGF-A Antibody, in Adult Patients with Advanced Solid Tumors. Clin Cancer Res. 2018 Apr 1;24(7):1536-1545. DOI:10.1158/1078-0432.CCR-17-1588
[2] Wolfgang Schaefer, et al. Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11187-92. DOI:10.1073/pnas.1019002108

Vanucizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Vanucizumab Suppliers

China 9 Global 9

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1448221-05-3, VanucizumabRelated Search:

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Vanucizumab

Research Grade Vanucizumab (DHA42302)

Research Grade Vanucizumab

1448221-05-3