Ligufalimab

Product Name: Ligufalimab
CAS No.: 2428381-55-7
Chemical Name: Ligufalimab
Synonyms: Ligufalimab;Ligufalimab (anti-CD47);Research Grade Ligufalimab;Research Grade Ligufalimab (DHG17606)
CBNumber: CB010617108
Formula Weight: 0
MOL File: Mol file

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Ligufalimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Ligufalimab Chemical Properties,Usage,Production

Uses

Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity[1].

in vivo

Ligufalimab (0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model) inhibits tumor growth in mice^[1].

Animal Model:	SCID/Beige mice (Raji xenograft model, MDA-MB-231 xenograft model)^[1]
Dosage:	0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model
Administration:	I.v.
Result:	Inhibited tumor growth with the tumor inhibition rate of 88.56%, 63.78% at 1, 0.1 mg/kg.

References

[1] Qu T, et al. Ligufalimab, a novel anti-CD47 antibody with no hemagglutination demonstrates both monotherapy and combo antitumor activity. J Immunother Cancer. 2022 Nov;10(11):e005517. DOI:10.1136/jitc-2022-005517

Ligufalimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Ligufalimab Suppliers

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2428381-55-7, LigufalimabRelated Search:

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Ligufalimab

Research Grade Ligufalimab (DHG17606)

Research Grade Ligufalimab

Ligufalimab (anti-CD47)

2428381-55-7