Lacnotuzumab

Product Name: Lacnotuzumab
CAS No.: 1831128-32-5
Chemical Name: Lacnotuzumab
Synonyms: Lacnotuzumab;Lacnotuzumab (anti-M-CSF);Research Grade Lacnotuzumab
CBNumber: CB28081030
Formula Weight: 0
MOL File: Mol file

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Lacnotuzumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Lacnotuzumab Chemical Properties,Usage,Production

Uses

Lacnotuzumab (MCS110) is a neutralizing humanized IgG1/κ monoclonal antibody targeting CSF-1 that prevents CSF-1 from activating the CSF-1R. Lacnotuzumab can be used for the research of pigmented villonodular synovitis[1][2].

in vivo

Lacnotuzumab neutralizes recombinant and serum-derived forms of cynomolgus CSF-1, but it does not recognize rodent or rabbit CSF-1^[2].

References

[1] Kuemmel S, et, al. A Randomized Phase II Study of Anti-CSF1 Monoclonal Antibody Lacnotuzumab (MCS110) Combined with Gemcitabine and Carboplatin in Advanced Triple-Negative Breast Cancer. Clin Cancer Res. 2022 Jan 1;28(1):106-115. DOI:10.1158/1078-0432.CCR-20-3955
[2] Pognan F, et, al. Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. J Pharmacol Exp Ther. 2019 Jun;369(3):428-442. DOI:10.1124/jpet.118.254128

Lacnotuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Lacnotuzumab Suppliers

China 15 United States 1 Global 16

Shanghai YuanYe Biotechnology Co., Ltd.

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1831128-32-5, LacnotuzumabRelated Search:

Prolgolimab Anatumomab Abelacimab Flotetuzumab Licaminlimab Tozorakimab Etevritamab Immunoglobulin G1,anti-(human NCA-90 granulocyte cell antigen) (mouse monoclonal IMMU-MN3 g1-chain), disulfide with mousemonoclonal IMMU-MN3 k-chain, dimer (9CI) Cosfroviximab Vobarilizumab

Lacnotuzumab

Research Grade Lacnotuzumab

Lacnotuzumab (anti-M-CSF)

1831128-32-5