Tozorakimab

Product Name: Tozorakimab
CAS No.: 2376858-66-9
Chemical Name: Tozorakimab
Synonyms: Tozorakimab;Tozorakimab (anti-IL-33);Research Grade Tozorakimab;Research Grade Tozorakimab (DHB74004)
CBNumber: CB410617030
Formula Weight: 0
MOL File: Mol file

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Tozorakimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Tozorakimab Chemical Properties,Usage,Production

Uses

Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease[1].

in vivo

Tozorakimab (0.1-10 mg/kg, i.p., once time) inhibits IL-5 levels in bronchoalveolar lavage fluid of humanized IL-33 genetically modified mice in dose-dependent manner^[2].

References

[1] Reid F, et al. Safety, pharmacokinetics and immunogenicity of the anti-interleukin-33 antibody, tozorakimab: results of a phase 1 study in healthy adults and patients with chronic obstructive pulmonary disease. American Thoracic Society. 2022: A2398-A2398.
[2] England E, et al. Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction. Sci Rep. 2023 Jun 17;13(1):9825. DOI:10.1038/s41598-023-36642-y

Tozorakimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Tozorakimab Suppliers

China 11 United States 1 Global 12

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd

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TargetMol Chemicals Inc.

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Guangzhou Hongyuan Chemical Co.,Ltd

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Wuhan Chemstan Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Biolab Reagents

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Wanxin Biotechnology (Jiaxing) Co., LTD

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Atagenix Laboratories

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AntibodySystem Laboratories SAS

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Tozorakimab

Research Grade Tozorakimab (DHB74004)

Research Grade Tozorakimab

Tozorakimab (anti-IL-33)

2376858-66-9