Lorvotuzumab Mertansine

Product Name: Lorvotuzumab Mertansine
CAS No.: 1008106-64-6
Chemical Name: Lorvotuzumab Mertansine
Synonyms: Lorvotuzumab Mertansine;Research Grade Lorvotuzumab;Lorvotuzumab mertansine (ADC);Research Grade Lorvotuzumab (DHC98501)
CBNumber: CB18080733
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Lorvotuzumab Mertansine Chemical Properties,Usage,Production

Uses

Lorvotuzumab mertansine is an ADC consisting of a humanized N901 monoclonal antibody against CD56 bound to maytansinoid DM1 via a stable disulfide linker. Lorvotuzumab mertansine has antitumor activity[1].

in vivo

Lorvotuzumab mertansine (3-51 mg/kg, i.v., once) has potent anti-tumour activity in CB.17 SCID mice with SW2 SCLC xenograft tumor^[1].

Animal Model:	SW2 SCLC xenograft tumor CB.17 SCID mice
Dosage:	3、17 and 51 mg/kg
Administration:	i.v., once
Result:	Showed high anti-tumor activity at a dose of 17 mg/kg with half of the animals being tumor free and complete tumor regression at a dose of 51 mg/kg.

References

[1] Kathleen R Whiteman, et al. Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models. MAbs. 2014 Mar-Apr;6(2):556-66. DOI:10.4161/mabs.27756

Lorvotuzumab Mertansine Preparation Products And Raw materials

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Lorvotuzumab Mertansine Suppliers

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1008106-64-6, Lorvotuzumab MertansineRelated Search:

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Lorvotuzumab Mertansine

Research Grade Lorvotuzumab (DHC98501)

Lorvotuzumab mertansine (ADC)

Research Grade Lorvotuzumab

1008106-64-6