Dostarlimab

Product Name: Dostarlimab
CAS No.: 2022215-59-2
Chemical Name: Dostarlimab
Synonyms: TSR-042;Dostarlimab;Dostarlimab (anti-PD-1);Research Grade Dostarlimab;Research Grade Dostarlimab (DHH02205)
CBNumber: CB48081100
Formula Weight: 0
MOL File: Mol file

More

Less

Dostarlimab Property

form: Liquid
color: Colorless to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

Dostarlimab Chemical Properties,Usage,Production

Uses

Dostarlimab (TSR-042) is a humanized anti-PD-1 monoclonal antibody. Dostarlimab binds with high affinity to human PD-1 and competitively inhibits its interaction with its ligands, PD-L1 and PD-L2, with IC50s of 1.8 and 1.5 nM, respectively[1].

in vivo

Dostarlimab (200 μg/mouse; i.p.; twice weekly for 35 days) shows antitumor activity in humanized mouse models^[1].

Animal Model:	Humanized NOG-EXL mice, A549 and MDA-MB-436 tumor model^[1]
Dosage:	200 μg/mouse
Administration:	Intraperitoneal injection; twice weekly for 35 days
Result:	Resulted in great inhibition of tumor growth in an A549 lung cancer model (tumor growth inhibition [TGI] of 62% at termination). The antitumor activity was associated with a reduction in tumor-associated regulatory T cells and a trend toward increased tumor-infiltrating CD8⁺ T cells. Inhibited tumor growth of MDA-MB-436 breast cancer model (TGI of 53%).

References

[1] Kumar S, et al. Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models. MAbs. 2021 Jan-Dec;13(1):1954136. DOI:10.1080/19420862.2021.1954136

Dostarlimab Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Dostarlimab Suppliers

China 17 United States 1 Global 18

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Guangzhou Hongyuan Chemical Co.,Ltd

Tel: 15817493340
Email: 981810490@qq.com
Country: China
ProdList: 1566
Advantage: 58

Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
Fax: QQ：422450190
Email: 422450190@qq.com
Country: China
ProdList: 10308
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Biolab Reagents

Tel: 027-65279366 18108604356
Email: products@biolabreagent.com
Country: China
ProdList: 9868
Advantage: 58

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 086-15871494362 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 6762
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509; 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 4970
Advantage: 58

2022215-59-2, DostarlimabRelated Search:

Suvratoxumab Demupitamab Ianalumab Cergutuzumab Amunaleukin Livmoniplimab Sudubrilimab Frexalimab Plamotamab Solitomab Lupartumab

Dostarlimab

Research Grade Dostarlimab (DHH02205)

TSR-042

Dostarlimab (anti-PD-1)

Research Grade Dostarlimab

2022215-59-2