Ianalumab
- Product Name
- Ianalumab
- CAS No.
- 1929549-92-7
- Chemical Name
- Ianalumab
- Synonyms
- VAY-736;Ianalumab;Research Grade Ianalumab;Ianalumab (anti-TNFRSF13C);Research Grade Ianalumab (DHJ42201)
- CBNumber
- CB58081046
- Formula Weight
- 0
- MOL File
- Mol file
Ianalumab Property
- form
- Liquid
- color
- Colorless to light yellow
Ianalumab Chemical Properties,Usage,Production
Uses
Ianalumab (VAY-736) is a human, decarboxylated antibody against BAFF-R. Ianalumab can block the interaction between BAFF and BAFF-R and antagonize the apoptosis protection mediated by BAFF. Ianalumab exerts antibody-dependent cytotoxic (ADCC), depending on effector cell activation mediated by immune receptor tyrosine activation motif (ITAM)[1].
in vivo
Ianalumab (Total: 100 mg/kg; once weekly for 2 weeks) increases in vivo survival in CLL mouse models[1].
Ianalumab (10 mg/kg; once weekly for 6 weeks) is enhanced by Ibrutinib (HY-10997) through an ITAM function on NK cells[1].
| Animal Model: | Em-TCL1 adoptive transplant model of murine CLL[1] |
| Dosage: | 10 mg/kg |
| Administration: | Injection; once weekly for 6 weeks |
| Result: | Ibrutinib enhanced VAY-736 activity through an ITAM function on NK cells. |
References
[1] McWilliams EM, et al. Anti-BAFF-R antibody VAY-736 demonstrates promising preclinical activity in CLL and enhances effectiveness of ibrutinib. Blood Adv. 2019 Feb 12;3(3):447-460. DOI:10.1182/bloodadvances.2018025684
Ianalumab Preparation Products And Raw materials
Raw materials
Preparation Products
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