Bedinvetmab
- Product Name
- Bedinvetmab
- CAS No.
- 2171034-69-6
- Chemical Name
- Bedinvetmab
- Synonyms
- Bedinvetmab;Research Grade Bedinvetmab;Research Grade Bedinvetmab (DQB91701)
- CBNumber
- CB88081148
- Formula Weight
- 0
- MOL File
- Mol file
Bedinvetmab Property
- form
- Liquid
- color
- Colorless to light yellow
Bedinvetmab Chemical Properties,Usage,Production
Uses
Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs[1][2].
in vivo
Bedinvetmab (0.5-1 mg/kg; s.c. for 28 d) alleviates the pain associated with canine osteoarthritis[1].
Bedinvetmab (1 mg/kg; s.c. monthly; 3× and 10× dose multiples) is well tolerated in normal laboratory Beagle dogs for 6 months and with 2 weeks' concurrent NSAID administration[2].
References
[1] Corral MJ, et, al. A prospective, randomized, blinded, placebo-controlled multisite clinical study of bedinvetmab, a canine monoclonal antibody targeting nerve growth factor, in dogs with osteoarthritis. Vet Anaesth Analg. 2021 Nov;48(6):943-955. DOI:10.1016/j.vaa.2021.08.001
[2] Krautmann M, et, al. Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs. Vet J. 2021 Oct;276:105733. DOI:10.1016/j.tvjl.2021.105733
Bedinvetmab Preparation Products And Raw materials
Raw materials
Preparation Products
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