Bertilimumab

Product Name: Bertilimumab
CAS No.: 375348-49-5
Chemical Name: Bertilimumab
Synonyms: Cat-213;Bertilimumab;Bertilimumab [inn];Research Grade Bertilimumab;Human anti-eotaxin 1 monoclonal antibody;Immunoglobulin G4, anti-(human eotaxin 1) (human monoclonal cat-213 gamma 4-chain), disulfide with human monoclonal cat-213 kappachain, dimer
CBNumber: CB42128706
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Bertilimumab Chemical Properties,Usage,Production

Uses

Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research[1].

in vivo

Bertilimumab (CAT 213) (0.01-10 mg/kg) administered i.v. 30 min before i.po. injection of human eotaxin1 (1 μg) causes a significant dose-dependent inhibition of eosinophil recruitment in IL-5-treated, ovalbumin-sensitized mice. Bertilimumab also significantly inhibits neutrophil and mononuclear cell influx into the air pouch, which resulted in a dose-related inhibition of total cell influx^[1].

Animal Model:	Female BALB/c mice (17-21 g) injected human eotaxin1^[1].
Dosage:	0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg
Administration:	i.v; once
Result:	Caused a significant dose-dependent inhibition of eosinophil recruitment in IL-5-treated, ovalbumin-sensitized mice.

References

[1] Sarah Main, et al. A potent human anti-eotaxin1 antibody, CAT-213: isolation by phage display and in vitro and in vivo efficacy. J Pharmacol Exp Ther. 2006 Dec;319(3):1395-404. DOI:10.1124/jpet.106.110734

Bertilimumab Preparation Products And Raw materials

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375348-49-5, BertilimumabRelated Search:

ofatumumab Adalimumab Bertilimumab Rituximab ipilimumab Rimteravimab Alsevalimab Iscalimab Atorolimumab h5G1.1-scFv

Bertilimumab [inn]

Cat-213

Human anti-eotaxin 1 monoclonal antibody

Immunoglobulin G4, anti-(human eotaxin 1) (human monoclonal cat-213 gamma 4-chain), disulfide with human monoclonal cat-213 kappachain, dimer

Bertilimumab

Research Grade Bertilimumab

375348-49-5