Iscalimab

Product Name: Iscalimab
CAS No.: 2031153-61-2
Chemical Name: Iscalimab
Synonyms: CFZ533;Iscalimab;Research Grade Iscalimab;Research Grade Iscalimab (DHD68901)
CBNumber: CB78081075
Formula Weight: 0
MOL File: Mol file

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Iscalimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Iscalimab Chemical Properties,Usage,Production

Uses

Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (KD: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases[1][2][3].

in vivo

Iscalimab (150 mg/kg/week, s.c, for 13 weeks) is well tolerated and does not cause any dose-limiting toxicity in rhesus monkeys^[3].
Iscalimab (10 mg/kg, i.v.) completely inhibits T cell-dependent antibody response in Rhesus monkeys^[3].
Iscalimab (30 mg/kg, i.v.) prolongs allograft survival in kidney transplant cynomolgus^[4].

Animal Model:	Kidney transplant cynomolgus^[4]
Dosage:	30 mg/kg
Administration:	i.v.
Result:	Prolonged allograft survival. Well-tolerated with no evidence of thromboembolic events or CD40 pathway activation.

IC 50

CD40: 0.3 nM (IC₅₀)

References

[1] Kahaly GJ, et al. A Novel Anti-CD40 Monoclonal Antibody, Iscalimab, for Control of Graves Hyperthyroidism-A Proof-of-Concept Trial. J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgz013. DOI:10.1210/clinem/dgz013
[2] Flandre TD, et al. Immunosuppression Profile of CFZ533 (Iscalimab), a Non-Depleting Anti-CD40 Antibody, and the Presence of Opportunistic Infections in a Rhesus Monkey Toxicology Study. Toxicol Pathol. 2022 Jul;50(5):712-724. DOI:10.1177/01926233221100168
[3] Ristov J, et al. Characterization of the in vitro and in vivo properties of CFZ533, a blocking and non-depleting anti-CD40 monoclonal antibody. Am J Transplant. 2018 Dec;18(12):2895-2904. DOI:10.1111/ajt.14872
[4] Cordoba F, et al. A novel, blocking, Fc-silent anti-CD40 monoclonal antibody prolongs nonhuman primate renal allograft survival in the absence of B cell depletion. Am J Transplant. 2015 Nov;15(11):2825-36. DOI:10.1111/ajt.13377

Iscalimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Iscalimab Suppliers

China 16 Global 16

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2031153-61-2, IscalimabRelated Search:

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Iscalimab

Research Grade Iscalimab (DHD68901)

Research Grade Iscalimab

CFZ533

2031153-61-2