Vopratelimab
- Product Name
- Vopratelimab
- CAS No.
- 2039148-04-2
- Chemical Name
- Vopratelimab
- Synonyms
- JTX 2011;Vopratelimab;Vopratelimab (anti-ICOS);Research Grade Vopratelimab;Research Grade Vopratelimab (DHJ92101)
- CBNumber
- CB38081077
- Formula Weight
- 0
- MOL File
- Mol file
Vopratelimab Property
- form
- Liquid
- color
- Colorless to light yellow
Vopratelimab Chemical Properties,Usage,Production
Uses
Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response[1].
in vivo
Vopratelimab (JTX-2011; 0.25-0.3 mg/kg; i.p.; twice a week, for 2 weeks) promotes tumor regression in the Sa1/N murine syngeneic tumor model[1].
| Animal Model: | Female A/J, Balb/c and C57BL/6 mice with Sa1/N murine syngeneic tumor model[1] |
| Dosage: | 0.25-0.3 mg/kg |
| Administration: | Intraperitoneal injection; twice a week, for 2 weeks |
| Result: | Regressed tumor and protected long-term in the Sa1/N murine syngeneic tumor model. |
References
[1] Hanson A, et, al. ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models. PLoS One. 2020 Sep 24;15(9):e0239595. DOI:10.1371/journal.pone.0239595
Vopratelimab Preparation Products And Raw materials
Raw materials
Preparation Products
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