Pharmacological action Uses
ChemicalBook > CAS DataBase List > Mecobalamin

Mecobalamin

Pharmacological action Uses
Product Name
Mecobalamin
CAS No.
13422-55-4
Chemical Name
Mecobalamin
Synonyms
METHYLCOBALAMIN;MECOBALAMINE;methylcobalamine;methycobal;Mecobalamin Tablets;vitamin B12 Mecobalamin;Mecobalamin(Methylcobalamin);Methyl-5,6-dimethylbenzimidazolylcobalamin;MeCbl;mbl-a
CBNumber
CB1106194
Molecular Formula
C63H90CoN13O14P
Formula Weight
1343.4
MOL File
13422-55-4.mol
More
Less

Mecobalamin Property

Melting point:
>190°C (dec.)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Sparingly), Water (Slightly)
pka
pK1:7.64(+1) (25°C)
form 
Solid
color 
Dark Red
Odor
Odorless
Water Solubility 
Partially soluble in cold water, hot water.
Stability:
Light Sensitie
InChI
InChI=1/C62H90N13O14P.CH2.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H2;/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52?,53-,56+,57+,59-,60+,61+,62+;;/s3
InChIKey
JEWJRMKHSMTXPP-WYVZQNDMSA-L
SMILES
[CH2-][Co+3]1234N5=CN([C@H]6O[C@H](CO)[C@@H](OP(O[C@H](C)CNC(=O)CC[C@]7(C)[C@@H](CC(=O)N)[C@@]8([H])[C@]9([C@@](C)(CC(=O)N)[C@H](CCC(=O)N)C(C(C)=C%10[C@@](C)(CC(=O)N)[C@H](CCC(=O)N)C(C=C%11C(C)(C)[C@H](CCC(=O)N)C(C(C)=C7[N-]18)=N2%11)=N3%10)=N49)C)([O-])=O)C6([H])O)C1=CC(C)=C(C)C=C51 |&1:5,7,10,14,22,24,29,31,32,38,48,54,66,r|
LogP
-2.812 (est)
CAS DataBase Reference
13422-55-4
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
2
RTECS 
GG3745000
HS Code 
29362600
Toxicity
LD50 oral in rat: > 5gm/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M9756
Product name
Methylcobalamin
Purity
vitamin B
Packaging
1g
Price
$803
Updated
2024/03/01
Sigma-Aldrich
Product number
1424550
Product name
Methylcobalamin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
2x150mg
Price
$447
Updated
2024/03/01
Alfa Aesar
Product number
A11176
Product name
Methylcobalamin hydrate, 98+%
Packaging
500mg
Price
$288
Updated
2021/12/16
Alfa Aesar
Product number
A11176
Product name
Methylcobalamin hydrate, 98+%
Packaging
100mg
Price
$73.4
Updated
2021/12/16
Cayman Chemical
Product number
29113
Product name
Methylcobalamin
Packaging
100mg
Price
$36
Updated
2024/03/01
More
Less

Mecobalamin Chemical Properties,Usage,Production

Pharmacological action

Mecobalamin as vitamin B12 derivatives, should be called "methyl vitamin B12" according to the chemical structure of name, the functional groups of methylation can be involved in the biochemical process of methyl transfer activity, promoting to nucleic acid of nerve tissue, the metabolism of protein and fat, , can stimulate the synthesis of lecithin Schwann cells, repairing the damaged myelin, improving nerve conduction velocity; directly into nerve cells, and stimulating axon regeneration of damaged area; stimulating protein synthesis in nerve cells and enhanced synthetic metabolism of axons to prevent axonal degeneration; involved in nucleic acid synthesis, promoted hematopoietic function. The treatment is clinically used in diabetic neuropathy, long-term use of macrovascular complications of diabetes are the curative effect.
Mecobalamin is used for peripheral nerve disorders treatment drug, compared with other vitamin B12 preparations, having good transfer on the nervous tissue, through the methyl transfer reaction, can promote nucleic acid, protein lipid metabolism, repairing the damaged nerve tissue. In homocysteine synthetic egg ammonia acid process, it plays a role of coenzyme, especially by deoxyuridine synthesis of thymidine, promoting DNA and RNA synthesis of participation. Also in the experiment of glial cells, the drugs can improve methionine synthase activity and promote the synthesis of myelin lipids lecithin. Improving the nerve tissue metabolism, can promot axis cable and protein synthesis, make the delivery rate of the skeletal protein close to normal, maintain axonal functions. Besides mecobalamin injections can inhibit nerve tissue of abnormal impulse conduction, promoting redl blood cells mature, split, improving anemia. Mecobalamin can be quickly restored due to lack of B12 and reduce the number of rat erythrocytes, hemoglobin, hematocrit value. Used for megaloblastic red blood cell anemia and peripheral nerve disorder due to the lack of vitamin B12.
The above information is edited by the Chemicalbook Hanya.

Uses

1.It is used for the treatment of nervous system diseases, relieving pain and numbness, speeded relieving pain, improving pain caused by cervical spondylosis, treatment of sudden deafness, etc.
2.Methylcobalamin is a kind of endogenous coenzyme B12, participating in the one carbon unit cycle, playing an important role in the synthesis of methionine homocysteine methyl transfer reaction process.

Description

Methylcobalamin is an analog of vitamin B12 with diverse neurological activities. It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 μM. Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine in a rat model of neuropathic pain. Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS). It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.

Chemical Properties

Dark Red Crystalline Powder

Physical properties

Vitamin B12 is an octahedral cobalt complex consisting of a porphyrin-like, cobalt centered macroring (called a corrin ring or nucleus). The corrinoids are red, red orange, or yellow crystalline substances that show intense absorption spectra above 300 nm owing to the π–π transitions of the corrin nucleus. They are soluble in water and are fairly stable to heat but decompose at temperatures above ～210 °C without melting.
Vitamin B12 reacts with ascorbic acid, resulting in the reduction and subsequent degradation of the former, which releases its cobalt atom as the free ion. Cobalamins are more stable in the presence of ascorbic acid but unstable to light

Uses

One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic).

Uses

Histamine receptor, Alzheimer research

Definition

A vitamin B 12 analog used as an intermediate in the synthesis of methane. It is responsible for the methylation of inorganic mercury by anaerobic bacteria in bottom sediments. Through the action of methylcobalamin in an anaerobic bacteria in bottom sediments of aquatic systems, arsenic(III) is methylated to methanearsonic acid then to cacodylic acid.

Side effects

Common side effects of Mecobalamin include: vomiting, diarrhoea, nausea, headache and loss of appetite. Rarely, hypotension, hypokalaemia and thrombocytosis occur. Serious allergic reactions are rare, contact your doctor if you experience hives, difficulty breathing, swelling of the face, lips, tongue or throat, difficulty breathing.

Mecobalamin Preparation Products And Raw materials

Raw materials

Vitamin B12

Preparation Products

More
Less

Mecobalamin Suppliers

Canada 1 China 408 Europe 2 Germany 2 India 44 Japan 3 South Korea 1 Switzerland 1 United Kingdom 3 United States 45 Global 510
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Creative Enzymes
Tel
1-516-855-7709
Fax
1-631-938-8127
Email
info@creative-enzymes.com
Country
United States
ProdList
8748
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
Olinax Inc.
Tel
--
Fax
--
Email
info@olinax.com
Country
United States
ProdList
404
Advantage
50
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
American International Chemical, Inc.
Tel
--
Fax
--
Email
info@aicma.com
Country
United States
ProdList
531
Advantage
58
Charkit Chemical Corporation
Tel
--
Fax
--
Email
sales@charkit.com
Country
United States
ProdList
2993
Advantage
65
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
235
Advantage
68
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
212
Advantage
30
Altan Corporation
Tel
--
Fax
--
Email
OrderingService@AltanBiochemicals.com
Country
United States
ProdList
1161
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
Empire Chemicals
Tel
--
Fax
--
Email
global@empirechemicals.com
Country
United States
ProdList
190
Advantage
38
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@par-chem.com
Country
United States
ProdList
740
Advantage
66
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
794
Advantage
76
Lab Express
Tel
--
Fax
--
Email
sales@labexpress.com
Country
United States
ProdList
1577
Advantage
67
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
ChromaDex
Tel
--
Fax
--
Email
sales@chromadex.com
Country
United States
ProdList
2501
Advantage
76
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
CGeneTech, Inc.
Tel
--
Fax
--
Email
qyu@cgenetech.com
Country
United States
ProdList
959
Advantage
30
More
Less

View Lastest Price from Mecobalamin manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Mecobalamin 13422-55-4
Price
US $999.00-666.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Mecobalamin 13422-55-4
Price
US $0.00-0.00/Kg/Bag
Min. Order
100g
Purity
98.0%-101.0%; CP
Supply Ability
10kg
Release date
2021-06-02
Hebei Chuanghai Biotechnology Co,.LTD
Product
Methylcobalamin 13422-55-4
Price
US $100.00-60.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10 ton
Release date
2024-08-22

13422-55-4, MecobalaminRelated Search:

METSULFURON METHYL Menadione Vitamin D3 Tribenuron methyl Pirimiphos-methyl Vitamin A Cocarboxylase DL-α-Tocopherol Methyl salicylate Ascorbic Acid Thiamine nitrate Methyl acetate Kresoxim-methyl Folic acid Thiophanate-methyl Riboflavin Methyl Vitamin E Mecobalamin Tablets

  • MECOBALAMIN
  • MECOBALAMINE
  • METHYLCOBALAMIN
  • cobalt-methylcobalamin
  • cobinamide,cobalt-methylderivative,hydroxide,dihydrogenphosphate(ester),
  • Methyl-5,6-dimethylbenzimidazolylcobalamin
  • Algobaz
  • Hitocobamin-M
  • MeCbl
  • Methylcobaz
  • METHYLCOBALAMIN(P)
  • methylcobalamine
  • methylvitaminb12
  • MecobalaminVitaminB12Jpxiu
  • Mecobalamin(Methylcobalamin)
  • Mecobalamin / Vitamin B12
  • methylated B12
  • Mecobalamin Tablets
  • Methylcobalamine (vitamin b12, Mecobalamin) USP grade
  • vitamin B12 Mecobalamin
  • Cobinamide, Co-methyl-, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3) (9CI)
  • innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidazole
  • mbl-a
  • methycobal
  • methyl-b12
  • Methylcobalamin[Mecobalamin]
  • VitaminB12 Derivatives
  • [5-(5,6-dimethyl-1-benzimidazolyl)-4-hydroxy-2-(hydroxymethyl)-3-oxolanyl] 1-[[1-oxo-3-[2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-oc
  • 6-dimethylbenzimidazolylcobalamin
  • Mecobalamin RS
  • CH3-B12
  • Cobametin
  • Vancomin
  • Methylcobalamin-13C-d3
  • Mecobalamin USP/EP/BP
  • B12 VITAMIN B12 USP/EP/BP
  • 4-Methylcyanocobalamin
  • MethylcobalaminQ: What is Methylcobalamin Q: What is the CAS Number of Methylcobalamin Q: What is the storage condition of Methylcobalamin Q: What are the applications of Methylcobalamin
  • Methylcobalamin (2 x 150 mg) (1424550)
  • Methylcobalamin vitamin B12
  • Methylcobalamin,inhibit,Endogenous Metabolite,Inhibitor
  • Vitamin B12 series
  • Methylcobalamin (Impurity)
  • Mthylcobalamin
  • Vitamin b12 Methylated (Methylcobalamin)
  • 13422-55-4
  • C63H91CoN13O14P
  • C63H91N13O14P
  • C63H91CoN13
  • C63H91N13O14PxH2O
  • API
  • Pharmaceutical intermediates
  • PHARMACEUTICALS
  • Nutritional Supplements
  • Intermediates & Fine Chemicals
  • Vitamin B12
  • Nutrition Research
  • Vitamins