Gatifloxacinacid

Product Name: Gatifloxacinacid
CAS No.: 121577-32-0
Chemical Name: Gatifloxacinacid
Synonyms: Gatifloxacinacid;AM 1155 hydrochloride;PD 135432 hydrochloride);BMS-206584 (hydrochloride);BMS 206584-01 hydrochloride;Gatifloxacin hydrochloride, 10 mM in DMSO;Gatifloxacin hydrochloride (AM 1155 hydrochloride;AM 1155 HYDROCHLORIDE;BMS 206584-01 HYDROCHLORIDE;PD 135432 HYDROCHLORIDE;3-Quinolinecarboxylicacid,1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1);3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-, Monohydrochloride (9CI)
CBNumber: CB11074612
Molecular Formula: C19H22FN3O4.ClH
Formula Weight: 411.859
MOL File: 121577-32-0.mol

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Gatifloxacinacid Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B1215
Product name: Gatifloxacinhydrochloride
Packaging: 1g
Price: $44
Updated: 2021/12/16

ChemScene

Product number: CS-1842
Product name: Gatifloxacin(hydrochloride)
Purity: >98.0%
Packaging: 500mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-1842
Product name: Gatifloxacin(hydrochloride)
Purity: >98.0%
Packaging: 1g
Price: $60
Updated: 2021/12/16

Axon Medchem

Product number: Axon3171
Product name: Gatifloxacinhydrochloride-AM-1155hydrochloride
Purity: 99%
Packaging: 250mg
Price: $99
Updated: 2021/12/16

ApexBio Technology

Product number: B1215
Product name: Gatifloxacinhydrochloride
Packaging: 5g
Price: $203
Updated: 2021/12/16

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Gatifloxacinacid Chemical Properties,Usage,Production

Uses

Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

Biological Activity

Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a potent fluoroquinolone antibiotic with broad-spectrum antimicrobial activity.

in vivo

Gatifloxacin hydrochloride (subcutaneous injection; 100 mg/kg; 3 times a day; 30 days) significantly decreases the number of lesions in mouse footpad with Nocardia brasiliensis .

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Animal Model:	Female BALB/c mice with Nocardia brasiliensis in the right hind footpad
Dosage:	100 mg/kg
Administration:	Subcutaneous injection; 3 times a day; 30 days
Result:	Reduced the production of lesions in mice.

target

Topoisomerase II

36.7 μM ()

IC 50

Quinolone; Topoisomerase II: 36.7 μM ()

References

[1] Takei M, et al. Inhibitory activities of Gatifloxacin hydrochloride (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.Antimicrob Agents Chemother.?1998 Oct;42(10):2678-81. DOI:10.1128/AAC.42.10.2678
[2] Fukuda H, et al. Antibacterial activity of Gatifloxacin hydrochloride (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother.?1998 Aug;42(8):1917-22. DOI:10.1128/AAC.42.8.1917
[3] Yamada C, et al. Gatifloxacin hydrochloride?acutely?stimulates?insulin?secretion?and?chronically?suppresses?insulin?biosynthesis. Eur J Pharmacol.?2006 Dec 28;553(1-3):67-72. Epub 2006 Sep 28. DOI:10.1016/j.ejphar.2006.09.043
[4] Daw-Garza A, et al. In?vivo?therapeutic?effect?of?Gatifloxacin mesylate?on?BALB/c?mice?infected?with?Nocardia?brasiliensis.Antimicrob Agents Chemother.?2008 Apr;52(4):1549-50. DOI:10.1128/AAC.00148-08

Gatifloxacinacid Preparation Products And Raw materials

Raw materials

Preparation Products

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Gatifloxacinacid Suppliers

China 45 Germany 1 India 1 United States 9 Global 56

ShangHai Caerulum Pharma Discovery Co., Ltd.

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LETOPHARM LIMITED

Tel: +86-21-5821 5861
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Country: China
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Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
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Country: China
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BOC Sciences

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Shanghai EFE Biological Technology Co., Ltd.

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Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

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Amadis Chemical Company Limited

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Beijing Jin Ming Biotechnology Co., Ltd.

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Musechem

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121577-32-0, GatifloxacinacidRelated Search:

Ciprofloxacin hydrochloride hydrate Gatifloxacin Gatifloxacin-D4 Hydrochloride Gatifloxacinacid 4-Fluoro-2-methoxyaniline hydrochloride Norfloxacin hydrochloride Ciprofloxacin DESETHYLENE CIPROFLOXACIN, HYDROCHLORIDE

Gatifloxacinacid

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-, Monohydrochloride (9CI)

3-Quinolinecarboxylicacid,1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1)

BMS 206584-01 hydrochloride

Gatifloxacin hydrochloride (AM 1155 hydrochloride

PD 135432 hydrochloride)

AM 1155 hydrochloride

AM 1155 HYDROCHLORIDE;BMS 206584-01 HYDROCHLORIDE;PD 135432 HYDROCHLORIDE

BMS-206584 (hydrochloride)

Gatifloxacin hydrochloride, 10 mM in DMSO

121577-32-0

C19H22FN3O4ClH