2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)
- Product Name
- 2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)
- CAS No.
- 54198-72-0
- Chemical Name
- 2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)
- Synonyms
- 2-Pyrimidinemethanol, 4,6-dimethyl-;(4,6-dimethylpyrimidin-2-yl)methanol;2-Pyrimidinemethanol, 4,6-dimethyl- (9CI)
- CBNumber
- CB11081447
- Molecular Formula
- C7H10N2O
- Formula Weight
- 138.17
- MOL File
- 54198-72-0.mol
2-Pyrimidinemethanol, 4,6-dimethyl- (9CI) Property
- Melting point:
- 87-88 °C
- Boiling point:
- 235.1±28.0 °C(Predicted)
- Density
- 1.130±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 13.75±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D495773
- Product name
- (4,6-Dimethylpyrimidin-2-yl)methanol
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 7790AB
- Product name
- (4,6-Dimethylpyrimidin-2-yl)methanol
- Packaging
- 1g
- Price
- $442
- Updated
- 2021/12/16
- Product number
- D15159
- Product name
- (4,6-Dimethylpyrimidin-2-yl)methanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 7790AB
- Product name
- (4,6-Dimethylpyrimidin-2-yl)methanol
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 7790AB
- Product name
- (4,6-Dimethylpyrimidin-2-yl)methanol
- Packaging
- 250mg
- Price
- $184
- Updated
- 2021/12/16
2-Pyrimidinemethanol, 4,6-dimethyl- (9CI) Chemical Properties,Usage,Production
Synthesis
27427-89-0
54198-72-0
General procedure for the synthesis of (4,6-dimethylpyrimidin-2-yl)methanol from methyl 4,6-dimethylpyrimidine-2-carboxylate: 4,6-dimethylpyrimidine-2-carboxylic acid methyl ester (400 mg, 2.40 mmol) was dissolved in ethanol (10 mL) under argon protection and cooled to 0 °C. Sodium borohydride (137 mg, 3.60 mmol) was then added and the reaction was slowly warmed to room temperature and stirred for 2 hours. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched with deionized water (15 mL) and extracted with dichloromethane (2 x 30 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product (4,6-dimethylpyrimidin-2-yl)methanol (285 mg, 86% yield) as a thick slurry. The crude product was used directly in the next reaction without further purification. The product was confirmed by 1H-NMR (CDCl3, 400 MHz): δ 6.91 (s, 1H), 4.71 (s, 2H), 2.50 (s, 6H). Liquid chromatography-mass spectrometry (LC-MS) analysis showed a purity of 96.66%, m/z 139.3 (M++1); chromatographic conditions: Eclipse XDB C-18 column (150×4.6 mm, 5 μm), mobile phase 0.05% trifluoroacetic acid/acetonitrile at a flow rate of 1.0 mL/min, and retention time of 4.03 min. TLC unfolding agent was 40% ethyl acetate/hexane (Rf=0.5).
References
[1] Patent: WO2013/142269, 2013, A1. Location in patent: Paragraph 0589; 0590; 0591
2-Pyrimidinemethanol, 4,6-dimethyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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