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2-(Di-tert-butylphosphino)biphenyl

Reactions
Product Name
2-(Di-tert-butylphosphino)biphenyl
CAS No.
224311-51-7
Chemical Name
2-(Di-tert-butylphosphino)biphenyl
Synonyms
JohnPhos;ditert-butyl-(2-phenylphenyl)phosphane;2-(DI-T-BUTYLPHOSPHINO)BIPHENYL;(2-biphenyl)di-tert-butylphosphine;JnhnPhos;98% JohnPhos;JohnPhos 97%;2-(Di-t-butyL;phosphino)biphenyL;Pyridaben Impurity 2
CBNumber
CB1108350
Molecular Formula
C20H27P
Formula Weight
298.4
MOL File
224311-51-7.mol
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2-(Di-tert-butylphosphino)biphenyl Property

Melting point:
86-88 °C (lit.)
Boiling point:
405.5±24.0 °C(Predicted)
Density 
1 g/cm3
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated, Sonicated)
form 
Crystals or Crystalline Powder
color 
White
Water Solubility 
Insoluble
BRN 
8322131
Stability:
Air Sensitive
InChI
InChI=1S/C20H27P/c1-19(2,3)21(20(4,5)6)18-15-11-10-14-17(18)16-12-8-7-9-13-16/h7-15H,1-6H3
InChIKey
CNXMDTWQWLGCPE-UHFFFAOYSA-N
SMILES
P(C1=CC=CC=C1C1=CC=CC=C1)(C(C)(C)C)C(C)(C)C
CAS DataBase Reference
224311-51-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
36/37/39-26-22
WGK Germany 
3
F 
10-23
TSCA 
No
HazardClass 
AIR SENSITIVE
HS Code 
29029090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
638439
Product name
JohnPhos
Purity
97%
Packaging
1g
Price
$61.3
Updated
2024/03/01
Sigma-Aldrich
Product number
638439
Product name
JohnPhos
Purity
97%
Packaging
5g
Price
$291
Updated
2024/03/01
TCI Chemical
Product number
D3387
Product name
2-(Di-tert-butylphosphino)biphenyl
Purity
>98.0%(GC)
Packaging
1g
Price
$73
Updated
2024/03/01
TCI Chemical
Product number
D3387
Product name
2-(Di-tert-butylphosphino)biphenyl
Purity
>98.0%(GC)
Packaging
5g
Price
$301
Updated
2024/03/01
Strem Chemicals
Product number
15-1045
Product name
2-(Di-t-butylphosphino))-1,1'-biphenyl, 99% JohnPhos
Packaging
500mg
Price
$29
Updated
2024/03/01
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2-(Di-tert-butylphosphino)biphenyl Chemical Properties,Usage,Production

Reactions

  1. Ligand used in the palladium-catalyzed synthesis of aromatic amines from aryl chlorides, bromides and triflates.
  2. Ligand employed in a very active and general catalyst for Suzuki coupling reactions using aryl chlorides, bromides and triflates.
  3. Ligand used in palladium-catalyzed synthesis of oxindoles from α-chloroacetanilides.
  4. Effective ligand used in palladium-catalyzed arylation of thiazoles.
  5. Used in the formation of 2-benzylindolines via sequential palladium-catalyzed N-arylation/cyclization/C-arylation.
  6. Selective in the palladium-catalyzed arylation of silyl enol ethers formed from copper-catalyzed reduction of enones.

Chemical Properties

white to light yellow crystal powde

Uses

suzuki reaction

Uses

2-(Di-tert-butylphosphino)biphenyl (also known as JohnPhos) is a Buchwald ligand that is highly efficient in palladium-catalyzed reactions.

General Description

JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy.

2-(Di-tert-butylphosphino)biphenyl Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Di-tert-butylphosphino)biphenyl Suppliers

Americas 1 Belgium 1 Canada 1 China 285 Europe 1 Germany 8 India 7 Japan 8 Norway 1 Russia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 9 United States 32 Global 359
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 2-(Di-tert-butylphosphino)biphenyl manufacturers

Shanghai UCHEM Inc.
Product
2-(Di-tert-butylphosphino)biphenyl 224311-51-7
Price
US $16.50-254.00/g
Min. Order
5g
Purity
0.98
Supply Ability
25kg
Release date
2023-10-25
Henan Research New Materials Co., Ltd.
Product
2-(Di-tert-butylphosphino)biphenyl 224311-51-7
Price
US $0.00/g
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2021-12-09
Hebei Weibang Biotechnology Co., Ltd
Product
2-(Di-tert-butylphosphino)biphenyl 224311-51-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2022-12-20

224311-51-7, 2-(Di-tert-butylphosphino)biphenylRelated Search:

tert-Butanol Tri-tert-butylphosphine Biphenyl Tributylphosphine Di-tert-butyl peroxide Butylated Hydroxytoluene T-BUTYLPHOSPHINE Di-tert-butylphosphine TERT-BUTYLPHOSPHONIC ACID 2-(DI-T-BUTYLPHOSPHINO)-2'-METHYLBIPHENYL 2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL (2-BIPHENYL)DI-TERT-BUTYLPHOSPHINE GOLD& RAC-2-(DI-T-BUTYLPHOSPHINO)-1,1'-BINAPHTHYL 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL 2-DI-TERT-BUTYLPHOSPHINO-3,4,5,6-TETRAM& 2-(Di-tert-butylphosphino)biphenyl 2-(2'-DI-TERT-BUTYLPHOSPHINE)BIPHENYLPALLADIUM(II) ACETATE 2,2'-BIS(DI-TERT-BUTYLPHOSPHINO)BIPHENYL

  • (2-biphenyl)di-tert-butylphosphine
  • (2-BIPHENYLYL)DI-TERT-BUTYLPHOSPHINE
  • 2-(DI-TERT-BUTYLPHOSPHINO)BIPHENYL
  • 2-(DI-T-BUTYLPHOSPHINO)BIPHENYL
  • BIPHENYL-2-YL-DI-TERT-BUTYL-PHOSPHANE
  • 2-(Di-t-butylphosphino)biphenyl,99%JohnPhos
  • 2-(Di-t-butylphosphine) biphenyl
  • PHOSPHINE, [1,1''-BIPHENYL]-2-YLBIS(1,1-DIMETHYLETHYL)-
  • JohnPhos
  • 2-(Di-tert-butylphosphino)-biphenyl, JohnPhos
  • (2-Biphenylyl)di-tert-butylphosphine, 2-(Di-tert-butylphosphino)biphenyl, JohnPhos
  • 2-(Di-tert-butylphosphino)biphenyl,99%
  • (2-Biphenyl)di-tert-butylphosphine,(2-Biphenylyl)di-tert-butylphosphine, 2-(Di-tert-butylphosphino)biphenyl, JohnPhos
  • 2-[Bis(tert-butyl)phosphino]biphenyl 98%
  • 2-(Di-t-butylphosphino)-1,1'- biphenyl (Johnphos)
  • 2-[Bis(tert-butyl)phosphino]biphenyl
  • 98% JohnPhos
  • (2-Biphenylyl)di-tert-butylphosphine JohnPhos
  • 2-(Di-tert-butylphosphino)biphenyl, 99% 500MG
  • 2-(Di-tert-butylphosphiNA)biphenyl
  • 2-(Di-t-butylphosphino)biphenyl, JohnPhos
  • [1,1'-biphenyl]-2-yldi-tert-butylphosphine
  • 2-(Di-t-butylphosphino)biphenyl,98% JohnPhos
  • 2-(Di-tert-butylphosphino)biph
  • 2-(Di-tert-butylphosphino)biphenyl (2-Biphenyl)di-tert-butylphosphine
  • JnhnPhos
  • JohnPhos 97%
  • 99% SynonyMs (2-Biphenyl)di-tert-butylphosphine
  • ditert-butyl-(2-phenylphenyl)phosphane
  • 2-(Di-t-butylphosphino))-1,1'-biphenyl
  • 2-(Di-t-butylphosphino))-1,1'-biphenyl, 99% JohnPhos
  • [1,1'-biphenyl]-2-yldi-tert-bu
  • 2-(Di-t-butylphosphino)
  • 2-(Di-tert-butylphosphino)biphenyl&gt
  • 2-(Di-t-butyL
  • phosphino)biphenyL
  • 2-(Di-tert-butylphosphino)-1,1'-biphenyl
  • 1,1'-Biphenyl]-2-ylbis(1,1-dimethylethyl)phosphine
  • itert-butyl-(2-phenylphenyl)phosphane
  • Pyridaben Impurity 2
  • 2-(Di-t-butylphosphino))-1,1'-biphenyl
  • [1,1'-Biphenyl]-2-ylbis(1,1-dimethylethyl)phosphine
  • 2- (di tert butyl phosphine) biphenyl
  • 1,1'-biphenyl]-2-yldi-tert-butylphosphine
  • 224311-51-7
  • C20H27P
  • C6H5C6H4PCCH332
  • Buchwald Ligands
  • Catalysis and Inorganic Chemistry
  • Phosphorus Compounds
  • Achiral Phosphine
  • Aryl Phosphine
  • Buchwald Ligands Series
  • Buchwald Ligands&Precatalysts
  • organophosphine ligand
  • Ligand
  • Benzene derivatives
  • Phosphines