5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE
- Product Name
- 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE
- CAS No.
- 875781-17-2
- Chemical Name
- 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE
- Synonyms
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine;EOS-61661;4-b]pyridine;5-BROMO-1H-PYRAZO[3;5-broMo-1H-pyrazolo[3;5-bromo-7-azaindazole;7-Aza-5-bromo-1H-indole;5-Bromopyrazolo[3,4-b]pyridine;5-bromo-1H-pyrazoio[3,4-b]pyridine;5-Bromopyrazolo[3,4-b]pyridine >
- CBNumber
- CB11092720
- Molecular Formula
- C6H4BrN3
- Formula Weight
- 198.02
- MOL File
- 875781-17-2.mol
5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Property
- Melting point:
- 198.0 to 202.0 °C
- Boiling point:
- 329.0±22.0 °C(Predicted)
- Density
- 1.894±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.66±0.40(Predicted)
- form
- Solid
- color
- White to Yellow to Orange
- InChI
- InChI=1S/C6H4BrN3/c7-5-1-4-2-9-10-6(4)8-3-5/h1-3H,(H,8,9,10)
- InChIKey
- BASYLPMLKGQZOG-UHFFFAOYSA-N
- SMILES
- C12NN=CC1=CC(Br)=CN=2
- CAS DataBase Reference
- 875781-17-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- ADE000064
- Product name
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- B4363
- Product name
- 5-Bromopyrazolo[3,4-b]pyridine
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $142
- Updated
- 2025/07/31
- Product number
- B688173
- Product name
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine
- Packaging
- 2.5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR43562
- Product name
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine
- Packaging
- 500mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 059425
- Product name
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Chemical Properties,Usage,Production
Uses
5-Bromo-1H-pyrazolo[3,4-b]pyridine is a pyridine (P998910) derivative and useful building block, seen in its use in the synthetic preparation of 7-?azaindazole chalcone derivatives as analgesics and anti-?inflammatories.
Synthesis
875781-15-0
875781-17-2
The general procedure for the synthesis of 5-bromo-1H-pyrazolo[3,4-b]pyridine from 5-bromo-2-fluoro-3-formylpyridine was as follows: preparation of 5-bromo-1H-pyrazolo[3,4-b]pyridine (D-1-3). Compound D-1-2 (20 g, 0.1 mol) was mixed with an ethanol solution of anhydrous hydrazine (18 g, 0.56 mol) and heated to reflux overnight. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was petroleum ether/ethyl acetate, 2:1, v/v) to confirm complete consumption of the raw material. Upon completion of the reaction, the reaction mixture was concentrated under vacuum to about 50 mL and subsequently poured into water (500 mL). The resulting mixture was filtered and the filter cake was washed sequentially with water (50mL x 3) and ether (20mL x 3). Finally, the filter cake was dried under vacuum to afford the target compound D-1-3 (9.0 g, 46% yield) as a yellow solid.
References
[1] Journal of Organic Chemistry, 2017, vol. 82, # 14, p. 7420 - 7427
[2] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 99-100
[3] Patent: WO2014/73904, 2014, A1. Location in patent: Paragraph 1496-1499
[4] Patent: CN103980272, 2016, B. Location in patent: Paragraph 0031; 0033
[5] Patent: WO2017/23987, 2017, A1. Location in patent: Paragraph 0610; 0612
5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE manufacturers
- Product
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine 875781-17-2
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 5-BROMO-1H-PYRAZO[3,4-B]PYRIDINE 875781-17-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- Minimum 98%
- Supply Ability
- 300kg
- Release date
- 2025-07-28
- Product
- 5-Bromo-1H-pyrazolo[3,4-b]pyridine 875781-17-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 100G
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-17