2-CHLORO-4-HYDROXYBENZONITRILE
Uses- Product Name
- 2-CHLORO-4-HYDROXYBENZONITRILE
- CAS No.
- 3336-16-1
- Chemical Name
- 2-CHLORO-4-HYDROXYBENZONITRILE
- Synonyms
- 3-Chloro-4-cyanophenol;Chloro-4-hydroxybenzonitrile;2-CHLORO-4-HYDROXYBENZONITRILE;Benzonitrile,2-chloro-4-hydroxy-;2-Chloro-4-hydroxybenzonitrile 98%;2-Chloro-4-hydroxybenzonitrile 98+%
- CBNumber
- CB1110443
- Molecular Formula
- C7H4ClNO
- Formula Weight
- 153.57
- MOL File
- 3336-16-1.mol
2-CHLORO-4-HYDROXYBENZONITRILE Property
- Melting point:
- 160 °C (dec.)(lit.)
- Boiling point:
- 323.2±27.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 6.88±0.18(Predicted)
- form
- powder
- color
- White
- InChIKey
- BDDVAWDNVWLHDQ-UHFFFAOYSA-N
- CAS DataBase Reference
- 3336-16-1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-37/39
- WGK Germany
- 3
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 346071
- Product name
- 2-Chloro-4-hydroxybenzonitrile
- Purity
- 98%
- Packaging
- 5g
- Price
- $182
- Updated
- 2023/06/20
- Product number
- 346071
- Product name
- 2-Chloro-4-hydroxybenzonitrile
- Purity
- 98%
- Packaging
- 10g
- Price
- $325
- Updated
- 2023/06/20
- Product number
- C422098
- Product name
- 2-Chloro-4-hydroxybenzonitrile
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- C422098
- Product name
- 2-Chloro-4-hydroxybenzonitrile
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR16169
- Product name
- 2-Chloro-4-hydroxybenzonitrile
- Purity
- 98+%
- Packaging
- 5g
- Price
- $66
- Updated
- 2021/12/16
2-CHLORO-4-HYDROXYBENZONITRILE Chemical Properties,Usage,Production
Uses
2-Chloro-4-hydroxybenzonitrile is used for preparation of arylthioamides.
Chemical Properties
white to light yellow crystal powder
Uses
2-Chloro-4-hydroxybenzonitrile may be used in the synthesis of 6-aminophenanthridines via Suzuki-Miyaura coupling reaction. It may be used in the preparation of 5-bromo-2-chloro-4-hydroxybenzonitrile.
Synthesis
20925-27-3
3336-16-1
Step 5: 2-Chloro-4-aminobenzonitrile (25 g, 0.187 mol) was added to a stirred mixture of concentrated sulfuric acid (58 g) and water (570 mL) and heated between 49 °C and 61 °C for about 30 minutes. The suspension was cooled to about 0°C and a cold solution of sodium nitrite (13.2 g, 0.187 mol) dissolved in water (125 mL) was slowly added dropwise over a temperature range of 0°C to 6°C. After the dropwise addition was completed, stirring of the reaction mixture was continued for about 3 hours. Subsequently, urea (1.5 g) was added to the mixture to quench the excess sodium nitrite. Insoluble impurities were removed by filtration. To the filtrate was added a 50% aqueous sulfuric acid solution (600 mL) while the reaction mixture was heated to between 74 °C and 81 °C with continuous stirring until the nitrogen stopped escaping. Upon completion of the reaction, the product was separated by filtration and purified with recrystallized water to give 2-chloro-4-hydroxybenzonitrile (17.9 g, 62.5% yield, melting point 160 °C).
References
[1] Patent: US4424371, 1984, A
2-CHLORO-4-HYDROXYBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-4-HYDROXYBENZONITRILE manufacturers
- Product
- 2-CHLORO-4-HYDROXYBENZONITRILE 3336-16-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
- Product
- 2-CHLORO-4-HYDROXYBENZONITRILE 3336-16-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-11
- Product
- 2-CHLORO-4-HYDROXYBENZONITRILE 3336-16-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06