ChemicalBook > CAS DataBase List > 2-CHLORO-4-HYDROXYBENZONITRILE

2-CHLORO-4-HYDROXYBENZONITRILE

Uses

Product Name: 2-CHLORO-4-HYDROXYBENZONITRILE
CAS No.: 3336-16-1
Chemical Name: 2-CHLORO-4-HYDROXYBENZONITRILE
Synonyms: 3-Chloro-4-cyanophenol;Chloro-4-hydroxybenzonitrile;2-CHLORO-4-HYDROXYBENZONITRILE;Benzonitrile,2-chloro-4-hydroxy-;2-Chloro-4-hydroxybenzonitrile 98%;2-Chloro-4-hydroxybenzonitrile 98+%
CBNumber: CB1110443
Molecular Formula: C7H4ClNO
Formula Weight: 153.57
MOL File: 3336-16-1.mol

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2-CHLORO-4-HYDROXYBENZONITRILE Property

Melting point:: 160 °C (dec.)(lit.)
Boiling point:: 323.2±27.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 6.88±0.18(Predicted)
form: powder
color: White
InChIKey: BDDVAWDNVWLHDQ-UHFFFAOYSA-N
CAS DataBase Reference: 3336-16-1

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 346071
Product name: 2-Chloro-4-hydroxybenzonitrile
Purity: 98%
Packaging: 5g
Price: $182
Updated: 2023/06/20

Sigma-Aldrich

Product number: 346071
Product name: 2-Chloro-4-hydroxybenzonitrile
Purity: 98%
Packaging: 10g
Price: $325
Updated: 2023/06/20

TRC

Product number: C422098
Product name: 2-Chloro-4-hydroxybenzonitrile
Packaging: 500mg
Price: $50
Updated: 2021/12/16

TRC

Product number: C422098
Product name: 2-Chloro-4-hydroxybenzonitrile
Packaging: 1g
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR16169
Product name: 2-Chloro-4-hydroxybenzonitrile
Purity: 98+%
Packaging: 1g
Price: $27
Updated: 2021/12/16

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2-CHLORO-4-HYDROXYBENZONITRILE Chemical Properties,Usage,Production

Uses

2-Chloro-4-hydroxybenzonitrile is used for preparation of arylthioamides.

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-4-hydroxybenzonitrile may be used in the synthesis of 6-aminophenanthridines via Suzuki-Miyaura coupling reaction. It may be used in the preparation of 5-bromo-2-chloro-4-hydroxybenzonitrile.

Synthesis

20925-27-3

3336-16-1

Step 5: 2-Chloro-4-aminobenzonitrile (25 g, 0.187 mol) was added to a stirred mixture of concentrated sulfuric acid (58 g) and water (570 mL) and heated between 49 °C and 61 °C for about 30 minutes. The suspension was cooled to about 0°C and a cold solution of sodium nitrite (13.2 g, 0.187 mol) dissolved in water (125 mL) was slowly added dropwise over a temperature range of 0°C to 6°C. After the dropwise addition was completed, stirring of the reaction mixture was continued for about 3 hours. Subsequently, urea (1.5 g) was added to the mixture to quench the excess sodium nitrite. Insoluble impurities were removed by filtration. To the filtrate was added a 50% aqueous sulfuric acid solution (600 mL) while the reaction mixture was heated to between 74 °C and 81 °C with continuous stirring until the nitrogen stopped escaping. Upon completion of the reaction, the product was separated by filtration and purified with recrystallized water to give 2-chloro-4-hydroxybenzonitrile (17.9 g, 62.5% yield, melting point 160 °C).

References

[1] Patent: US4424371, 1984, A

2-CHLORO-4-HYDROXYBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4-HYDROXYBENZONITRILE Suppliers

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View Lastest Price from 2-CHLORO-4-HYDROXYBENZONITRILE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-CHLORO-4-HYDROXYBENZONITRILE 3336-16-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

Shaanxi Dideu Medichem Co. Ltd

Product: 2-CHLORO-4-HYDROXYBENZONITRILE 3336-16-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-11

Career Henan Chemical Co

Product: 2-CHLORO-4-HYDROXYBENZONITRILE 3336-16-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-06

3336-16-1, 2-CHLORO-4-HYDROXYBENZONITRILERelated Search:

2-CHLORO-4-(PIPERIDIN-4-YLOXY)BENZONITRILE 2-CHLORO-3,4-DIMETHOXYBENZONITRILE 2-CHLORO-4-METHOXYBENZONITRILE 5-CHLORO-2-HYDROXYBENZONITRILE,5-Chloro-2-hydroxybenzonitrile, tech 3-CHLORO-4-HYDROXYBENZONITRILE 2-chloro-4-hydroxy-5-nitrobenzonitrile 5-amino-2-chloro-4-hydroxybenzonitrile CHLOROTHALONIL-4-HYDROXY 2-CHLORO-4-HYDROXYBENZONITRILE 3-Bromo-5-chloro-2-hydroxybenzonitrile 2-CHLORO-5-HYDROXYBENZONITRILE 3-chloro-2-hydroxybenzonitrile 2-CHLORO-6-HYDROXYBENZONITRILE 2-CHLORO-4-(PIPERIDIN-3-YLOXY)-BENZONITRILE AURORA KA-6314 AURORA KA-6176 4-(3-Chloro-4-cyano-phenoxymethyl)-piperidine-1-carboxylic acid tert-butyl ester AKOS B029092

2-CHLORO-4-HYDROXYBENZONITRILE

Chloro-4-hydroxybenzonitrile

Benzonitrile,2-chloro-4-hydroxy-

2-Chloro-4-hydroxybenzonitrile 98+%

3-Chloro-4-cyanophenol

2-Chloro-4-hydroxybenzonitrile 98%

3336-16-1

ClC6H3OHCN

C6 to C7

Building Blocks

Cyanides/Nitriles

Nitrogen Compounds

Organic Building Blocks

Aromatic Nitriles

C6 to C7

Cyanides/Nitriles

Nitrogen Compounds