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Amlodipine mesylate

Product Name
Amlodipine mesylate
CAS No.
246852-12-0
Chemical Name
Amlodipine mesylate
Synonyms
Amlodipine mesylate USP/EP/BP;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,methanesulfonic acid
CBNumber
CB11106917
Molecular Formula
C20H25ClN2O5.CH4O3S
Formula Weight
0
MOL File
246852-12-0.mol
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Amlodipine mesylate Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0014471
Product name
AMLODIPINE MESYLATE
Purity
95.00%
Packaging
5MG
Price
$495.12
Updated
2021/12/16
Matrix Scientific
Product number
095040
Product name
3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
AK Scientific
Product number
1891AB
Product name
3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylatemethanesulfonate
Packaging
250mg
Price
$1051
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0014471
Product name
AMLODIPINE MESYLATE
Purity
95.00%
Packaging
1G
Price
$1575
Updated
2021/12/16
Matrix Scientific
Product number
095040
Product name
3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
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Amlodipine mesylate Chemical Properties,Usage,Production

Uses

Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer[1][2][3].

in vivo

Amlodipine mesylate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice[4].
Amlodipine mesylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3].

Animal Model:ATP2B1loxP/loxP mice[4]
Dosage:5 mg/kg/day
Administration:Subcutaneously implanted osmotic pump for 2 weeks
Result:Significantly decreased the blood pressure.

IC 50

L-type calcium channel

References

[1] Kishen G. Bulsara, et al. Amlodipine.
[2] Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. DOI:10.2165/00003495-199550030-00009
[3] Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. DOI:10.1016/j.ejphar.2004.04.006
[4] Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. DOI:10.1038/hr.2017.92

Amlodipine mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Amlodipine mesylate Suppliers

China 27 India 4 United States 3 Global 34
TargetMol Chemicals Inc.
Tel
+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19962
Advantage
58
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
AvaChem Scientific LLC
Tel
--
Fax
--
Email
Info@avachem.com
Country
United States
ProdList
315
Advantage
30
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View Lastest Price from Amlodipine mesylate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Amlodipine mesylate 246852-12-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-12
Shaanxi Dideu Medichem Co. Ltd
Product
Amlodipine Mesylate 246852-12-0
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
600 MT
Release date
2020-05-08

246852-12-0, Amlodipine mesylateRelated Search:

Amlodipine Amlodipine Besylate (S)-Amlodipine Amlodipine mesylate

  • 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate
  • 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di
  • 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,methanesulfonic acid
  • Amlodipine mesylate USP/EP/BP
  • 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1
  • 246852-12-0
  • C21H29ClN2O8S
  • C20H25ClN2O5CH4O3S