ChemicalBook > CAS DataBase List > (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- Product Name
- (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- CAS No.
- 220246-81-1
- Chemical Name
- (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- Synonyms
- OR-1896;OR 1896,OR1896;Levosimendan Impurity 51;13C,2H3]-Levosimendan metabolite;(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-p;(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone;(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide;(R)-N-[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-acetamide;Acetamide, N-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]-
- CBNumber
- CB11120951
- Molecular Formula
- C13H15N3O2
- Formula Weight
- 245.28
- MOL File
- 220246-81-1.mol
More
Less
(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Property
- Melting point:
- 224-226°C
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.67±0.60(Predicted)
- color
- Pale Yellow to Light Yellow
- CAS DataBase Reference
- 220246-81-1
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- A168260
- Product name
- (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- Packaging
- 25mg
- Price
- $790
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA17089
- Product name
- (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- Packaging
- 1mg
- Price
- $105
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA17089
- Product name
- (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- Packaging
- 2mg
- Price
- $164
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0113919
- Product name
- OR-1896
- Purity
- 98.90%
- Packaging
- 5mg
- Price
- $280
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA17089
- Product name
- (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- Packaging
- 5mg
- Price
- $328.1
- Updated
- 2021/12/16
More
Less
(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
A metabolite of Levosimendan (L378000).
Definition
ChEBI: OR-1896 is an anilide and a member of acetamides.
in vivo
During the metabolism of Levosimendan approximately 5% of the drug is converted to the metabolite OR-1855 in the large intestine, and then acetylated in the liver to form the active metabolite OR-1896. Binding to plasma proteins is 98% for Levosimendan but only 40% for OR-1896. Unlike Levosimendan, which has an elimination half-life of 1-1.5 h, the half-life of OR-1896 is about 75 to 80 h allowing cardiovascular effects to persist up to 7 to 9 days after discontinuation of a 24-hour infusion of levosimendan. The pharmacokinetic of the parent drug is unaltered in subjects with severe renal impairment or with moderate hepatic impairment, whereas the elimination of its metabolites (OR-1896) can be prolonged[1].
IC 50
PDE3/PDE Ⅲ; K+ Channel; Drug Metabolite
(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 0755-83725681-603
- Fax
- +86 755 28094224
- Country
- China
- ProdList
- 4496
- Advantage
- 50
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- 020-36607679 19925672674
- Fax
- QQ 3008233717
- 3008233746@qq.com
- Country
- China
- ProdList
- 9883
- Advantage
- 12
- Tel
- 021-61263375 18168859245
- Country
- China
- ProdList
- 5958
- Advantage
- 58
- Tel
- 86-714-3992388
- overseasales1@yongstandards.com
- Country
- United States
- ProdList
- 14332
- Advantage
- 58
220246-81-1, (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinoneRelated Search:
(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
Levosimendan Impurity 14
Levosimendan
6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
LevosiMendan iMpurity
Levosimendan Impurity 4
2-[2-[4-(2-Azidotetrahydro-3-Methyl-5-oxo-2-furanyl)phenyl]hydrazinylidene]propanedinitrile (Mixture of DiasteroMers)
5-Methyl-3(2H)-pyridazinone
(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
Levosimendan Impurity 20
Levosimendan Impurity 47
Levosimendan Impurity 42
Granisetron Impurity 7 HCl
Acetic acid, 2-[2-[4-[(2R)-4-amino-2-methyl-1,4-dioxobutyl]phenyl]hydrazinylidene]-2-cyano-, (2Z)-
Levosimendan Impurity 60
Levosimendan Impurity 10