ChemicalBook > CAS DataBase List > (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

Product Name: (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
CAS No.: 220246-81-1
Chemical Name: (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
Synonyms: OR-1896;OR 1896,OR1896;Levosimendan Impurity 51;13C,2H3]-Levosimendan metabolite;(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-p;(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone;(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide;(R)-N-[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-acetamide;Acetamide, N-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]-
CBNumber: CB11120951
Molecular Formula: C13H15N3O2
Formula Weight: 245.28
MOL File: 220246-81-1.mol

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(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Property

Melting point:: 224-226°C
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 13.67±0.60(Predicted)
color: Pale Yellow to Light Yellow
CAS DataBase Reference: 220246-81-1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A168260
Product name: (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
Packaging: 25mg
Price: $790
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17089
Product name: (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
Packaging: 1mg
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17089
Product name: (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
Packaging: 2mg
Price: $164
Updated: 2021/12/16

ChemScene

Product number: CS-0113919
Product name: OR-1896
Purity: 98.90%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17089
Product name: (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
Packaging: 5mg
Price: $328.1
Updated: 2021/12/16

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(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

A metabolite of Levosimendan (L378000).

Definition

ChEBI: OR-1896 is an anilide and a member of acetamides.

in vivo

During the metabolism of Levosimendan approximately 5% of the drug is converted to the metabolite OR-1855 in the large intestine, and then acetylated in the liver to form the active metabolite OR-1896. Binding to plasma proteins is 98% for Levosimendan but only 40% for OR-1896. Unlike Levosimendan, which has an elimination half-life of 1-1.5 h, the half-life of OR-1896 is about 75 to 80 h allowing cardiovascular effects to persist up to 7 to 9 days after discontinuation of a 24-hour infusion of levosimendan. The pharmacokinetic of the parent drug is unaltered in subjects with severe renal impairment or with moderate hepatic impairment, whereas the elimination of its metabolites (OR-1896) can be prolonged^[1].

IC 50

PDE3/PDE Ⅲ; K+ Channel; Drug Metabolite

(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Suppliers

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220246-81-1, (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinoneRelated Search:

(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Levosimendan Impurity 14 Levosimendan 6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone LevosiMendan iMpurity Levosimendan Impurity 4 2-[2-[4-(2-Azidotetrahydro-3-Methyl-5-oxo-2-furanyl)phenyl]hydrazinylidene]propanedinitrile (Mixture of DiasteroMers) 5-Methyl-3(2H)-pyridazinone (R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Levosimendan Impurity 20 Levosimendan Impurity 47 Levosimendan Impurity 42 Granisetron Impurity 7 HCl Acetic acid, 2-[2-[4-[(2R)-4-amino-2-methyl-1,4-dioxobutyl]phenyl]hydrazinylidene]-2-cyano-, (2Z)- Levosimendan Impurity 60 Levosimendan Impurity 10

(R)-N-[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-acetamide

OR-1896

(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide

Acetamide, N-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]-

(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-p

13C,2H3]-Levosimendan metabolite

OR 1896,OR1896

(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

Levosimendan Impurity 51

220246-81-1

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