BOC-D-NVA-OH

Product Name: BOC-D-NVA-OH
CAS No.: 57521-85-4
Chemical Name: BOC-D-NVA-OH
Synonyms: N-Boc-D-norvaline dicyclohexylammonium salt;BOC-D-NORVALINE;Boc-D-Norvaline-OH;Boc-D-Nva;NSC 343953;BOC-D-NVA-OH;Boc-D-NVal-OH;Cbz-D-Norvaline;BOC-D-APE(2)-OH;RARECHEM EM WB 0169
CBNumber: CB1112861
Molecular Formula: C10H19NO4
Formula Weight: 217.26
MOL File: 57521-85-4.mol

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BOC-D-NVA-OH Property

Boiling point:: 348.3±25.0 °C(Predicted)
Density: 1.081±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: Powder
pka: 4.02±0.20(Predicted)
color: White
BRN: 5260625
CAS DataBase Reference: 57521-85-4(CAS DataBase Reference)

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Safety

WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 12688
Product name: Boc-D-Nva-OH
Purity: ≥98.0% (TLC)
Packaging: 5G
Price: $650
Updated: 2022/05/15

Usbiological

Product number: 264825
Product name: Boc-D-norvaline
Packaging: 2g
Price: $333
Updated: 2021/12/16

TRC

Product number: B657025
Product name: BOC-D-NVA-OH
Packaging: 25g
Price: $250
Updated: 2021/12/16

Usbiological

Product number: 236214
Product name: Boc-D-norvaline
Packaging: 1g
Price: $163
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB47813
Product name: Boc-D-norvaline (syrup)
Packaging: 10g
Price: $200.5
Updated: 2021/12/16

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BOC-D-NVA-OH Chemical Properties,Usage,Production

Chemical Properties

Clear colorless viscid liquid

Uses

BOC-D-NVA-OH is a chemical reagent used in the preparation of benzothiophene inhibitors of MK2. Also has been used to synthesize pyrrolidine diketopiperazines to inhibit melanoma

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

2013-12-9

24424-99-5

57521-85-4

General procedure for the synthesis of (R)-2-((tert-butylcarbonyl)amino)pentanoic acid from D-norvaline and di-tert-butyl dicarbonate: (R)-2-aminopentanoic acid (2.343 g) and Na2CO3 (2.120 g) were dissolved in water (60.00 mL) to form a mixture. A solution of THF (20 mL) in Boc2O (4.88 mL) was added slowly and dropwise to the mixture at room temperature. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was washed with ether (2 × 20 mL), followed by adjusting the pH of the aqueous phase with K2SO4 solution to 3. The aqueous phase was extracted with EtOAc (2 × 30 mL), the organic phases were combined, and the solvents were evaporated after drying to give (R)-2-((tert-butylcarbonyl)amino)pentanoic acid (4 g) as a viscous oil product. Mass spectrometry (ESI) analysis showed that the theoretical molecular weight of C10H19NO4 was 217; the measured value was 216 [M-H].

References

[1] Patent: US5206235, 1993, A
[2] Patent: WO2015/180612, 2015, A1. Location in patent: Page/Page column 70

BOC-D-NVA-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-NVA-OH Suppliers

China 97 France 1 Germany 3 India 3 Japan 2 Switzerland 2 United Kingdom 3 United States 18 Global 129

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
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Energy Chemical

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Wuhan Chemwish Technology Co., Ltd

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Email: sales@chemwish.com
Country: China
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Shanghai Hanhong Scientific Co.,Ltd.

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Email: info@hanhongsci.com
Country: China
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Chemsky (shanghai) International Co.,Ltd

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Email: shchemsky@sina.com
Country: China
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Shandong Xiya Chemical Co., Ltd

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Tianjin heowns Biochemical Technology Co., Ltd.

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Beijing HuaMeiHuLiBiological Chemical

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9ding chemical ( Shanghai) Limited

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

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View Lastest Price from BOC-D-NVA-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-D-NVal-OH 57521-85-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-10-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: BOC-D-NVA-OH 57521-85-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: BOC-D-NVA-OH 57521-85-4
Price: US $1.00/g
Min. Order: 100g
Purity: >98%
Supply Ability: g/kg/Ton
Release date: 2020-01-14

57521-85-4, BOC-D-NVA-OHRelated Search:

BOC-GLN-ONP Boc-D-Glutamine Nα-Boc-Nω-nitro-D-arginine N-Boc-N'-(2-chlorobenzyloxycarbonyl)-L-lysine Boc-D-Glu-OBzl BOC-D-LEU-OH H2O BOC-D-NLE-OH Boc-D-isoleucine (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid BOC-D-Leucine monohydrate BOC-D-ORN(Z)-OH BOC-D-Arg(Tos)-OH BOC-D-PRO-OSU Boc-D-homophenylalanine Boc-L-Glutamic acid 1-benzyl ester BOC-L-NVA-OH D(-)-Norvaline L-Norvaline

BOC-D-NHCH[CH3(CH2)]-COOH

BOC-D-NORVALINE

N-ALPHA-T-BUTOXYCARBONYL-D-2-AMINO-PENTANOIC ACID

N-ALPHA-T-BUTOXYCARBONYL-D-NORVALINE

N-ALPHA-T-BOC-D-NORVALINE

(R)-2-(BOC-AMINO)PENTANOIC ACID

RARECHEM EM WB 0169

Cbz-D-Norvaline

Boc-D-Nva

BOC-D-NORVALINE LIQUID

O-(PHENYLMETHYL)-L-THREONINE

(R)-2-(Boc-amino)pentanoic acid, Boc-D-norvaline

Boc-D-Norvaline-OH

Boc-D-norvaline (syrup)

NSC 343953

Boc-D-Nva-OH Boc-D-Norvaline

N-tert-Butoxycarbonyl-D-norvaline

N-Boc-D-norvaline dicyclohexylammonium salt

BOC-D-APE(2)-OH

BOC-D-2-AMINOVALERIC ACID

BOC-D-NVA-OH

N-(tert-butoxycarbonyl)norvaline

Boc-D-NVal-OH

Boc-D-norvaline (syrup)99%

D-Norvaline, N-[(1,1-dimethylethoxy)carbonyl]-

BOC-D-NVA-OH USP/EP/BP

(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid

Boc-<sc>D</sc>-Nva-OH

N-tert-butoxycarbonyl-D-norvaline, 97%min

57521-85-4

C10HNO4

Specialty Synthesis

Unnatural Amino Acid Derivatives

Peptide Synthesis

Amino Acids