7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Product Name: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS No.: 100361-18-0
Chemical Name: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Synonyms: 7-Chloro-1-cycloprop;Nalidixic acid cyclopropyl;7-Chloro-1-cyclopropyl-6-fluor;Gemifloxacin 7-Chloro Impurity;8-naphthyridine-3-carboxylic acid;7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1;1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1;7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-Ox;(S)-2-aMino-3-(2,4-diMethylphenyl)propanoic acid;1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyl ridine carbox.acid
CBNumber: CB1114830
Molecular Formula: C12H8ClFN2O3
Formula Weight: 282.65
MOL File: 100361-18-0.mol

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7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Property

Melting point:: 209-212 °C
Boiling point:: 485.9±45.0 °C(Predicted)
Density: 1.727±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 5.96±0.70(Predicted)
color: White to Almost white
CAS DataBase Reference: 100361-18-0

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2650
Product name: 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $57
Updated: 2025/07/31

TCI Chemical

Product number: C2650
Product name: 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $284
Updated: 2025/07/31

TRC

Product number: C365115
Product name: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylicAcid
Packaging: 1g
Price: $1055
Updated: 2021/12/16

Matrix Scientific

Product number: 072529
Product name: 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Purity: 95+%
Packaging: 1g
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC301100
Product name: 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylicacid
Packaging: 5g
Price: $75
Updated: 2021/12/16

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7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white or light yellow powder

Uses

Gemifloxacin intermediate as antibacterial agent.

Synthesis

96568-07-9

100361-18-0

Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate (0.1 g, 0.32 mmol) was used as a raw material and dissolved in THF (5 ml). Concentrated HCl (45 μL, 0.7 mmol) was added to this solution. The reaction mixture was heated to reflux and the reaction was continued for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. The precipitated solid was collected by filtration to afford the target product 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid in a yield of 70 mg with 78% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2428 - 2433
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 25, p. 5564 - 5575
[3] Patent: WO2005/40164, 2005, A1. Location in patent: Page/Page column 10-12

7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Suppliers

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View Lastest Price from 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid manufacturers

Changzhou waston chemical technology Co.,Ltd

Product: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 100361-18-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: As your request
Release date: 2025-11-03

Hebei Chuanghai Biotechnology Co., Ltd

Product: 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 100361-18-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Henan Fengda Chemical Co., Ltd

Product: 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 100361-18-0
Price: US $50.00-1.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: g-kg-tons,free sample is available
Release date: 2024-01-03

100361-18-0, 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acidRelated Search:

3-Chloropropyne Calcium chloride Ammonium chloride 3-Chloropropyltrimethoxysilane Choline chloride Cyclohexanecarboxylic acid Cyclopropanecarboxylic acid Sodium chloride 1-Chloronaphthalene Nalidixic acid Cyclopropyl methyl ketone 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid Allyl chloride Potassium chloride Malaridine Difluorochloromethane Methylene Chloride Fluorine

7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridin-3-Carboxylic Acid

1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyl ridine carbox.acid

7-Chloro-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Qxoquinoline-3-CarboxylicAcid98%

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicacid

7-Chloro-1-cyclopropyl-6-fluor

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-Ox

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1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYLRIDINE CARBOXYLIC ACID 99%

1-CYCLOPROPYL-6-FLUORO-7-CHLORIDE-4-OXO-1,4-DIHYDRO-1,8-NAPTHYRIDINE-3-CARBOXYLIE ACID

1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYLPYRIDINECARBOXYLIC ACID

1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid

1-Cyclopropyl-6-Fluoro-7-Chloro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylie acid

1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1

7-Chloro-1-cycloprop

Nalidixic acid cyclopropyl

3-Carboxy-7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine

(S)-2-aMino-3-(2,4-diMethylphenyl)propanoic acid

1,8-Naphthyridine-3-carboxylicacid, 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-

1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid, 95+%

7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

1-CYCLOPROPYL-6-FLUORO-7-CHLORIDE-4-OXO-1,4-DIHYDRO-1,8-NAPTHYRIDINE-3-CARBOXYLIC ACID

7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic

1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Gemifloxacin 7-Chloro Impurity

7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-CarboxylicAci

8-naphthyridine-3-carboxylic acid

7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1

7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

100361-18-0

C12H8FClN2O3

Fluorine series

Heterocycles

Intermediate

Intermediates & Fine Chemicals

Pharmaceuticals