ChemicalBook > CAS DataBase List > CYCLOBENZAPRINE HCL

CYCLOBENZAPRINE HCL

Product Name
CYCLOBENZAPRINE HCL
CAS No.
303-53-7
Chemical Name
CYCLOBENZAPRINE HCL
Synonyms
CYCLOBENZAPRINE;mk130;MK-130;RP-9715;9715r.p.;ro4-1577;Ro-4-1577;Proeptatriene;proheptatrien;Proheptatriene
CBNumber
CB1116384
Molecular Formula
C20H21N
Formula Weight
275.39
MOL File
303-53-7.mol
More
Less

CYCLOBENZAPRINE HCL Property

Boiling point:
bp1 175-180°
Density 
0.9504 (rough estimate)
refractive index 
1.7500 (estimate)
pka
pKa 8.47 (Uncertain)
BCS Class
1
NIST Chemistry Reference
Cyclobenzaprine(303-53-7)
More
Less

Safety

Hazardous Substances Data
303-53-7(Hazardous Substances Data)
Toxicity
LD50 oral in mouse: 250mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
KIT7835
Product name
Cyclobenzaprine(1.0mg/mLinMethanol)
Packaging
5x1ml
Price
$105
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009177
Product name
CYCLOBENZAPRINE
Purity
95.00%
Packaging
5MG
Price
$497.28
Updated
2021/12/16
AHH
Product number
MT-49581
Product name
Cyclobenzaprine
Purity
98%
Packaging
0.05g
Price
$410
Updated
2021/12/16
More
Less

CYCLOBENZAPRINE HCL Chemical Properties,Usage,Production

Description

Cyclobenzaprine is structurally similar to tricyclic antidepressants. It acts at the brain stem level.

Originator

Flexeril,Merck Sharp andDohme,US,1977

Uses

It is used as an adjuvant agent for relieving muscle spasms associated with severe diseased conditions of the muscle. A synonym of this drug is flexeril.

Uses

Relaxant (muscle).

Definition

ChEBI: 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its h drochloride salt in the symptomatic treatment of painful muscle spasm.

Manufacturing Process

In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.

brand name

Flexeril (McNeil).

Therapeutic Function

Muscle relaxant

Synthesis

Cyclobenzaprine, N,N-dimethyl-3-(dibenzo[a,d]cyclohepten-5-ylidene) propylamine (15.3.9), is synthesized by reacting 5H-dibenzo[a,d]cyclohepten-5-one with 3-dimethylaminopropylmagnesium chloride and subsequent dehydration of the resulting carbinol (15.3.8) in acidic conditions into cyclobenzaprine (15.3.9).

CYCLOBENZAPRINE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CYCLOBENZAPRINE HCL Suppliers

Canada 1 China 39 Europe 2 India 10 Italy 1 Spain 1 United Kingdom 4 United States 12 Global 70
SynFine Research
Tel
--
Fax
--
Email
research@synfine.com
Country
United States
ProdList
1024
Advantage
68
CacheSyn Inc.
Tel
--
Fax
--
Email
info@cachesyn.com
Country
United States
ProdList
695
Advantage
50
EJY Tech, Inc.
Tel
--
Fax
--
Country
United States
ProdList
448
Advantage
30
AmplaChem, Inc.
Tel
--
Fax
--
Email
info@amplacheminc.com
Country
United States
ProdList
428
Advantage
50
Amfinecom Inc.
Tel
--
Fax
--
Email
sales@amfinecom.com
Country
United States
ProdList
3062
Advantage
50
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
ACIC Fine Chemicals Inc.
Tel
--
Fax
--
Email
sales@acic.com
Country
United States
ProdList
492
Advantage
48
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Alltech Associates, Inc.
Tel
--
Fax
--
Email
alltech@alltechemail.com
Country
United States
ProdList
419
Advantage
60
Ceres Chemical Co. Inc.
Tel
--
Fax
--
Email
chemceres@aol.com
Country
United States
ProdList
50
Advantage
51
More
Less

View Lastest Price from CYCLOBENZAPRINE HCL manufacturers

XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
CYCLOBENZAPRINE HCL 303-53-7
Price
US $15.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
500MT/month
Release date
2021-12-20
Career Henan Chemical Co
Product
CYCLOBENZAPRINE HCL 303-53-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

303-53-7, CYCLOBENZAPRINE HCLRelated Search:

Paroxetine Gabapentin Cycloheptatriene PROTRIPTYLINE CYCLOBENZAPRINE HCL Cyclobenzaprine-d3 N-Oxide Benzaprinoxide Cyproheptadine Cyclobenzaprine N-Oxide Cyproheptadine hydrochloride sesquihydrate CYCLOBENZAPRINE HCL

  • CYCLOBENZAPRINE
  • CYCLOBENZAPRINE HCL
  • 10,11-dehydroamitriptyline
  • 1-Propanamine, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-
  • 3-(5h-dibenzo(a,d)cyclohepten-5-ylidene)-n,n-dimethyl-1-propanamin
  • 3-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
  • 5-(3-Dimetilaminopropiliden)-5H-dibenzo-(a,d)-ciclopentene
  • 5H-Dibenzo(a,d)cycloheptene-delta<sup>5</sup>,gamma-propylamine, N,N-dimethyl-
  • Cyclobenzaprine (base and/or unspecified salts)
  • Cyclobenzaprine base
  • 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-diMethylpropan-1-aMine
  • Cyclobenzaprine Impurity 1
  • 9715r.p.
  • d)cycloheptene-delta(sup5),gamma-propylamine,n,n-dimethyl-5h-dibenzo(
  • mk130
  • MK-130
  • n,n-dimethyl-5h-dibenzo(a,d)cycloheptene-delta(sup5),gamma-propylamine
  • N,N-Dimethyl-5H-dibenzo(a,d)cycloheptene-delta<sup>5</sup>,gamma-propylamine
  • Proeptatriene
  • proheptatrien
  • Proheptatriene
  • Ro-4-1577
  • ro4-1577
  • RP-9715
  • Nortriptyline Impurity 5 (Nortriptyline EP Impurity E)
  • CYCLOBENZAPRINE HCL USP/EP/BP
  • Cyclobenzaprine (1.0 mg/mL in Methanol)
  • RSYY（Avanafil)-49
  • 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine (cyclobenzaprine)
  • b.3-(5h-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine(cyclobenzaprine),
  • 303-53-7
  • C20H21N