ChemicalBook > CAS DataBase List > 5-O-Desmethyl Donepezil

5-O-Desmethyl Donepezil

Product Name: 5-O-Desmethyl Donepezil
CAS No.: 120013-57-2
Chemical Name: 5-O-Desmethyl Donepezil
Synonyms: Donepezil Impurity 28;Donepezil Impurity 59;Donepezil 5-O-Desmethyl Imp;Donepezil 5-hydroxy Impurity;Donepezil 5-O-Desmethyl Impurity;1-Benzyl-4-[(5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methylpiperidine;2-[(1-benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one;2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-5-hydroxy-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-;2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one hydrochloride
CBNumber: CB11175991
Molecular Formula: C23H27NO3
Formula Weight: 365.47
MOL File: 120013-57-2.mol

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5-O-Desmethyl Donepezil Property

Melting point:: 170-172°C
Boiling point:: 545.3±50.0 °C(Predicted)
Density: 1.190±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly, Heated)
form: Solid
pka: 8.16±0.40(Predicted)
color: White to Pale Brown
CAS DataBase Reference: 120013-57-2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D292010
Product name: 5-O-DesmethylDonepezil
Packaging: 5mg
Price: $350
Updated: 2021/12/16

TRC

Product number: D292010
Product name: 5-O-DesmethylDonepezil
Packaging: 2.5mg
Price: $185
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21262
Product name: 5-O-Desmethyl donepezil
Packaging: 2mg
Price: $272.6
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21262
Product name: 5-O-Desmethyl donepezil
Packaging: 1mg
Price: $149.9
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21262
Product name: 5-O-Desmethyl donepezil
Packaging: 5mg
Price: $495.5
Updated: 2021/12/16

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5-O-Desmethyl Donepezil Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A metabolite of Donepezil, an inhibitor of acetylcholinesterase

Uses

A metabolite of Donepezil (D531750), an inhibitor of acetylcholinesterase.

Definition

ChEBI: 5-O-desmethyldonepezil is a member of the class of piperidines that is donepezil in which the 5-methoxy group has been demethylated to the corresponding hydroxy derivative. It is metabolite of donepezil, a drug used in the treatment of dementia. It has a role as a drug metabolite. It is a member of piperidines, a cyclic ketone, an aromatic ether and a member of guaiacols.

5-O-Desmethyl Donepezil Preparation Products And Raw materials

Raw materials

Preparation Products

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120013-57-2, 5-O-Desmethyl DonepezilRelated Search:

Donepezil Hydrochloride Donepezil Donepezil Impurity 17 HCl 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine 2-[(1-Benzylpiperidin-4-yl)hydroxyMethyl]-5,6-diMethoxyindan-1-one RAC (CIS/TRANS) DONEPEZIL N-OXIDE XWAIAVWHZJNZQQ-RPXFAUAJSA-N 2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE 3,5-Dichloro-4-hydroxypyridine Donepezil Impurity 6-O-Desmethyl Donepezil β-D-Glucuronide 2-isonicotinoyl-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one 5,6-DIMETHOXY-2-PYRIDIN-4-YLMETHYL-INDAN-1-ONE 5,6-Dimethoxy-1-indanone 4-PYRIDINECARBOXALDEHYDE N-OXIDE Donepezil Impurity 8 5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one Dihydro Donepezil (Mixture of Diastereomers)

1-Benzyl-4-[(5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methylpiperidine

2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one

2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one hydrochloride

Donepezil 5-O-Desmethyl Impurity

Donepezil Impurity 28

Donepezil 5-O-Desmethyl Imp

2-[(1-benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one

1H-Inden-1-one, 2,3-dihydro-5-hydroxy-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-

Donepezil Impurity 59

Donepezil 5-hydroxy Impurity

120013-57-2

Heterocycles

Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

Intermediates & Fine Chemicals

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Pharmaceuticals