ChemicalBook > CAS DataBase List > 5-O-Desmethyl Donepezil

5-O-Desmethyl Donepezil

Product Name
5-O-Desmethyl Donepezil
CAS No.
120013-57-2
Chemical Name
5-O-Desmethyl Donepezil
Synonyms
Donepezil Impurity 28;Donepezil Impurity 59;Donepezil 5-O-Desmethyl Imp;Donepezil 5-hydroxy Impurity;Donepezil 5-O-Desmethyl Impurity;1-Benzyl-4-[(5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methylpiperidine;2-[(1-benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one;2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-5-hydroxy-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-;2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one hydrochloride
CBNumber
CB11175991
Molecular Formula
C23H27NO3
Formula Weight
365.47
MOL File
120013-57-2.mol
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5-O-Desmethyl Donepezil Property

Melting point:
170-172°C
Boiling point:
545.3±50.0 °C(Predicted)
Density 
1.190±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly, Heated)
form 
Solid
pka
8.16±0.40(Predicted)
color 
White to Pale Brown
CAS DataBase Reference
120013-57-2
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D292010
Product name
5-O-DesmethylDonepezil
Packaging
5mg
Price
$350
Updated
2021/12/16
TRC
Product number
D292010
Product name
5-O-DesmethylDonepezil
Packaging
2.5mg
Price
$185
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21262
Product name
5-O-Desmethyl donepezil
Packaging
2mg
Price
$272.6
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21262
Product name
5-O-Desmethyl donepezil
Packaging
1mg
Price
$149.9
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21262
Product name
5-O-Desmethyl donepezil
Packaging
5mg
Price
$495.5
Updated
2021/12/16
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5-O-Desmethyl Donepezil Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A metabolite of Donepezil, an inhibitor of acetylcholinesterase

Uses

A metabolite of Donepezil (D531750), an inhibitor of acetylcholinesterase.

Definition

ChEBI: 5-O-desmethyldonepezil is a member of the class of piperidines that is donepezil in which the 5-methoxy group has been demethylated to the corresponding hydroxy derivative. It is metabolite of donepezil, a drug used in the treatment of dementia. It has a role as a drug metabolite. It is a member of piperidines, a cyclic ketone, an aromatic ether and a member of guaiacols.

5-O-Desmethyl Donepezil Preparation Products And Raw materials

Raw materials

Preparation Products

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120013-57-2, 5-O-Desmethyl DonepezilRelated Search:


  • 1-Benzyl-4-[(5-hydroxy-6-methoxy-1-oxo-indan-2-yl)methylpiperidine
  • 2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one
  • 2-((1-benzylpiperidin-4-yl)methyl)-5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one hydrochloride
  • Donepezil 5-O-Desmethyl Impurity
  • Donepezil Impurity 28
  • Donepezil 5-O-Desmethyl Imp
  • 2-[(1-benzylpiperidin-4-yl)methyl]-5-hydroxy-6-methoxy-2,3-dihydroinden-1-one
  • 1H-Inden-1-one, 2,3-dihydro-5-hydroxy-6-methoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-
  • Donepezil Impurity 59
  • Donepezil 5-hydroxy Impurity
  • 120013-57-2
  • Heterocycles
  • Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals