L-3,4-DIFLUOROPHENYLALANINE

Product Name: L-3,4-DIFLUOROPHENYLALANINE
CAS No.: 31105-90-5
Chemical Name: L-3,4-DIFLUOROPHENYLALANINE
Synonyms: L-3,4-DIFLUOROPHE;H-PHE(3,4-F 2)-OH;H-PHE(3,4-DIF)-OH;L-Phe(3,4-DiF)-OH;H-D-PHE(M,P-F2)-OH;H-L-Phe(3,4-F2)-OH;RARECHEM BK PT 0121;L-3,4-Difluoro-phe-OH;H-3,4-DIFLUORO-L-PHE-OH;4-Difuoro-L-phenylalanine
CBNumber: CB1122899
Molecular Formula: C9H9F2NO2
Formula Weight: 201.17
MOL File: 31105-90-5.mol

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L-3,4-DIFLUOROPHENYLALANINE Property

Boiling point:: 311.9±42.0 °C(Predicted)
Density: 1.379±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
pka: 2.16±0.20(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 31105-90-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: D451195
Product name: 3,4-Difluoro-L-phenylalanine
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: D451195
Product name: 3,4-Difluoro-L-phenylalanine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 273873
Product name: L-3,4-Difluorophenylalanine
Packaging: 500mg
Price: $333
Updated: 2021/12/16

Apolloscientific

Product number: PC8363
Product name: 3,4-Difluoro-L-phenylalanine
Packaging: 5g
Price: $333
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD48010
Product name: L-3,4-Difluorophenylalanine
Packaging: 2g
Price: $350
Updated: 2021/12/16

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L-3,4-DIFLUOROPHENYLALANINE Chemical Properties,Usage,Production

Chemical Properties

Off-white solid powder

Synthesis

112897-97-9

31105-90-5

GENERAL METHODS: Suitable aldehydes 1j, 1n, or 1o (0.5 mmol), malonic acid (1.0 mmol), and piperidine (0.01 mmol) were dissolved in DMSO (500 mL), and the mixture was subsequently heated in a microwave reactor (60°C, 30 min). Upon completion of the reaction, the mixture was cooled to room temperature and ammonia solution (9.5 mL, 13% w/v, ~7 M, adjusted to pH 10.0 by slow addition of dry ice) was added, followed by addition of excess E. coli BL21(DE3) cells (400 mg wet cell paste) to catalyze the production of the target product, 3,4-difluoro-L-phenylalanine. The suspension was stirred at 37°C for several hours and the progress of the reaction was monitored by HPLC. To isolate the product, the reaction mixture was acidified to pH < 2.0 using aqueous sulfuric acid (20% w/v), followed by centrifugation (8000 rpm, 5 min) to remove the cells and the unconverted substrate precipitate. Dowex 50WX8 hydrogen-based resin (5.0 g) was loaded into a disposable plastic column and washed sequentially with deionized water (20 mL) and aqueous sulfuric acid solution (20 mL, 5% w/v). The supernatant after biotransformation was upsampled to the resin column at a flow rate of 1 mL/min. The resin bed was first rinsed with deionized water until the effluent was neutral, and then the product was eluted with aqueous ammonia solution (20 mL, 5% w/v). The product-containing fractions were combined and dried overnight in a centrifugal evaporator to give the corresponding L-phenylalanine derivatives L-3j, L-3n, or L-3o as white solids.4.7.1. (S)-2-Amino-3-(3,4-difluorophenyl)propionic acid (L-3j). Yield: 84 mg (84%), ee value 99% by HPLC.1H NMR (D2O/NaOH, 400 MHz), δ: 7.03-7.18 (m, 2H), 6.90-6.99 (m, 1H), 3.36-3.44 ( m, 1H), 2.81-2.90 (dd, J = 13.6, 6.0 Hz, 1H), 2.70-2.79 (dd, J = 13.6, 7.2 Hz, 1H).13C NMR (D2O/NaOH, 101 MHz), δ: 182.06, 150.94 ( dd, 1JCF = 243 Hz, 2JCF = 12 Hz), 150.09 (dd, 1JCF = 242 Hz, 2JCF = 13 Hz), 135.33 (dd, 3JCF = 5 Hz, 4JCF = 3 Hz), 125.51 (dd, 3JCF = 6 Hz, 4JCF = 3 Hz), 117.83 (d, 2JCF = 17 Hz), 116.97 (dd, 2JCF = 17 Hz), 57.33, 39.94. HRMS (ESI), m/z: calculated value 202.0680 [M?H]? , measured value 202.0689 [M?H]?

References

[1] Tetrahedron, 2016, vol. 72, # 46, p. 7256 - 7262

L-3,4-DIFLUOROPHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-3,4-DIFLUOROPHENYLALANINE Suppliers

China 92 Germany 4 India 1 Japan 1 United Kingdom 3 United States 20 Global 121

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View Lastest Price from L-3,4-DIFLUOROPHENYLALANINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-3,4-DIFLUOROPHENYLALANINE 31105-90-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: L-3,4-DIFLUOROPHENYLALANINE 31105-90-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-31

31105-90-5, L-3,4-DIFLUOROPHENYLALANINERelated Search:

L-3,5-DIFLUOROPHE L-2-(5-Bromothienyl)alanine L-4-THIAZOLYLALANINE L-2-Bromophenylalanine 3-(2-Naphthyl)-L-alanine 3,3-Diphenyl-L-alanine 3,4-Dichlorophenylalanine 2,3,4-Trifluoro-L-phenylalanine L-3,4-DIFLUOROPHENYLALANINE BOC-L-3,4-DIFLUOROPHENYLALANINE,tert-butoxycarbonyl-l-3,4-difluorophenylalanine,Boc-3,4-difluorophenylalanine,N-TERT-BUTOXYCARBONYL-L-3,4-DIFLUOROPHENYLALANINE FMOC-D-3,4-Difluorophe N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-3,4-DIFLUOROPHENYLALANINE,FMOC-L-3,4-DIFLUOROPHENYLALANINE,Fluorenylmethoxycarbonyl-L-3,4-difluorophenylalanine 3,4-DIFLUOROPHENYLALANINE,Difluorophenylalanine4,DL-3,4-DIFLUOROPHENYLALANINE BOC-L-3,5-DIFLUOROPHENYLALANINE D-2,4-Difluorophenylalanine DL-2,5-DIFLUOROPHENYLALANINE,2,5-DIFLUOROPHENYLALANINE,Difluorophenylalanine21 FMOC-D-3,5-DIFLUOROPHENYLALANINE L-2,5-Difluorophenylalanine

RARECHEM BK PT 0121

(S)-2-AMINO-3-(3,4-DIFLUORO-PHENYL)-PROPIONIC ACID

H-PHE(3,4-DIF)-OH

H-PHE(3,4-F 2)-OH

L-3,4-DIFLUOROPHE

L-3,4-DIFLUOROPHENYLALANINE

H-D-PHE(M,P-F2)-OH

H-3,4-DIFLUORO-L-PHE-OH

3,4-DIFLUORO-L-PHENYLALANINE

(2S)-2-amino-3-(3,4-difluorophenyl)propanoic acid

3-(3,4-Difluorophenyl)-L-alanine

H-L-Phe(3,4-F2)-OH

3,4-Difuoro-L-phenylalanine

4-Difuoro-L-phenylalanine

L-3,4-Difluorophenylalanine H-3,4-difluoro-L-Phe-OH

L-Phenylalanine,3,4-difluoro-

L-3,4-Difluorophenylalanine98+%

L-Phe(3,4-DiF)-OH

(S)-2-AMino-3-(3,4-difluorophenyl)propanoic acid

L-3,4-Difluoro-phe-OH

(2S)-2-amino-3-(3,4-difluorophenyl)propanoicaci

L-3,4-DIFLUOROPHENYLALANINE USP/EP/BP

31105-90-5

Phenylalanine analogs and other aromatic alpha amino acids

Amino Acids